caa a22 4500 467979014 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01973459 doi (NATIONALLICENCE)springer-10.1007/BF01973459 Distribution of the bispyridinium oxime [14C] HI-6 in male and female rats [Elektronische Daten] [Paul Lundy, Brian Hand, Brian Broxup, George Yipchuck, Murray Hamilton] Female rats poisoned with multiple LD50s of soman or tabun have been shown previously to respond to the protective effects of HI-6 more positively than male rats. This present study was designed first to determine the distribution pattern and concentration of [14C] HI-6 in rats, and secondly, to determine the possibility that HI-6 might be located in high concentrations in critical tissues in the female as opposed to the male. To these ends, [14C] HI-6 was administered to groups of male and female rats and its radiolabelled distribution determined by whole body autoradiography and/or by measurement of its actual concentration, by scintillation spectrometry. The experiments were repeated in the presence of 2 × LD50 soman and supporting therapy with atropine. In both sexes, HI-6 levels were highest in the kidney, followed in order by cartilage >plasma >liver >heart >lung > diaphragm >brain and spinal cord. The relative distribution in the two sexes was confirmed by both methods and was not significantly altered in the presence of soman and atropine. The lack of a measurable difference in tissue distribution of [14C] HI-6 derived radioactivity between males and females suggested that the hormone-dependent difference in the protective effects previously observed was not due to selective accumulation of [14C] HI-6 in organs believed to be important in its therapeutic activity, such as brain or diaphragm. Springer-Verlag, 1990 HI-6 nationallicence Tissue distribution nationallicence Soman nationallicence Autoradiography nationallicence Gender differences nationallicence Lundy Paul Defence Research Establishment Suffield, TOJ2NO, Ralston, Alberta, Canada aut Hand Brian Defence Research Establishment Suffield, TOJ2NO, Ralston, Alberta, Canada aut Broxup Brian Bio-Research Laboratories Limited Senneville, Québec, Canada aut Yipchuck George Bio-Research Laboratories Limited Senneville, Québec, Canada aut Hamilton Murray Defence Research Establishment Suffield, TOJ2NO, Ralston, Alberta, Canada aut Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 377-382 0340-5761 64:5<377 1990 64 204 https://doi.org/10.1007/BF01973459 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01973459 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lundy Paul Defence Research Establishment Suffield, TOJ2NO, Ralston, Alberta, Canada aut NATIONALLICENCE 700 1- Hand Brian Defence Research Establishment Suffield, TOJ2NO, Ralston, Alberta, Canada aut NATIONALLICENCE 700 1- Broxup Brian Bio-Research Laboratories Limited Senneville, Québec, Canada aut NATIONALLICENCE 700 1- Yipchuck George Bio-Research Laboratories Limited Senneville, Québec, Canada aut NATIONALLICENCE 700 1- Hamilton Murray Defence Research Establishment Suffield, TOJ2NO, Ralston, Alberta, Canada aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 377-382 0340-5761 64:5<377 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer