caa a22 4500 467979022 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01973470 doi (NATIONALLICENCE)springer-10.1007/BF01973470 Urinary arginine and ornithine in occupational exposure to 2-ethylhexanoic acid [Elektronische Daten] [Sirpa Pennanen, Alii Manninen, H. Savolainen] Nine sawmill workers were divided into two groups according to their exposure to 2-ethylhexanoic acid, (EHA), a pesticide which has replaced the older pentochlorophenol. The men with lower exposure excreted 30±10 nmol EHA/mmol creatinine (mean ±SD,n=4) in urine samples taken after the workshift, whereas men with higher exposure excreted 1.8±1.6 μmol EHA/mmol creatinine (mean±SD,n=5,p<0.01). The urinary ornithine and arginine concentrations were at the lower exposure 1.4±0.4 and 1.5±0.8 μmol/mmol creatinine, respectively (mean±SD,n=4), and they increased significantly (p<0.01) to 4.5±2.5 and 3.2±1.5μmol/mmol (mean±SD,n=5), respectively, at the higher exposure. This might have been caused by the inhibitory effect of EHA on urea synthesis which was partially compensated for by elevated arginine and ornithine concentrations to drive the urea cycle more efficiently. Springer-Verlag, 1990 2-Ethylhexanoic acid nationallicence Urea cycle nationallicence Arginine nationallicence Ornithine nationallicence Subclinical toxicity nationallicence Pennanen Sirpa National Public Health Institute, Kuopio, Finland aut Manninen Alii Regional Institute of Occupational Health, Kuopio, Finland aut Savolainen H. Institute of Occupational Health Sciences, University of Lausanne, Lausanne, Switzerland aut Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 426-427 0340-5761 64:5<426 1990 64 204 https://doi.org/10.1007/BF01973470 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01973470 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pennanen Sirpa National Public Health Institute, Kuopio, Finland aut NATIONALLICENCE 700 1- Manninen Alii Regional Institute of Occupational Health, Kuopio, Finland aut NATIONALLICENCE 700 1- Savolainen H. Institute of Occupational Health Sciences, University of Lausanne, Lausanne, Switzerland aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 426-427 0340-5761 64:5<426 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer