caa a22 4500 467979030 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01973457 doi (NATIONALLICENCE)springer-10.1007/BF01973457 Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats [Elektronische Daten] [E. Elovaara, H. Vainio, A. Aitio] Pulmonary changes in glutathione (GSH) indicated by the concentration of non-protein sulphydryls showed a decrease of 43% in rats exposed for 5 h per day three times to 500 cm3/m3 (2100 mg/m3) styrene vapour. In these rats, only a marginal decrease was observed in the pulmonary cytochrome P450 oxidative metabolism. Following a single 24-h inhalation exposure to 500 cm3/m3 styrene, the decreases in GSH were 66% in lung but only 16% in liver. On the other hand, a multifold increase in the disposition of thioether compounds was found in urine. Pulmonary cytochrome P450-dependent metabolism was decreased, shown by low residual activities of 7-ethoxyresorufin (<20%), 7-ethoxycoumarin (53%) and 7-pentoxyresorufin O-dealkylases (76%). Epoxide hydrolase and GSH S-transferase enzyme activities which catalyze styrene detoxification were not decreased. Styrene exposure (24 h) of acetone-, phénobarbitalor 3-methylcholanthrene-pretreated rats resulted in pulmonary effects different from each other and from those of styrene alone. Acetone potentiated the lung effect and elevated 1.5-fold urine thioether output. Inducer pretreatment seemed to be a factor aggravating styrene toxicity; in effect this was clearest in acetone-induced rats. In general, GSH depletion accompanied by inhibition of cytochrome P450-dependent oxidative drug metabolism were the earliest biochemical lesions manifested in styrene-exposed lung. Springer-Verlag, 1990 Styrene inhalation nationallicence Phenobarbital nationallicence Methylcholanthrene nationallicence Acetone nationallicence Microsomal drug-metabolizing enzymes nationallicence Glutathione nationallicence Thioethers nationallicence Lung nationallicence Liver nationallicence Rat nationallicence Elovaara E. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250, Helsinki, Finland aut Vainio H. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250, Helsinki, Finland aut Aitio A. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250, Helsinki, Finland aut Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 365-369 0340-5761 64:5<365 1990 64 204 https://doi.org/10.1007/BF01973457 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01973457 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elovaara E. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250, Helsinki, Finland aut NATIONALLICENCE 700 1- Vainio H. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250, Helsinki, Finland aut NATIONALLICENCE 700 1- Aitio A. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Topeliuksenkatu 41 a A, SF-00250, Helsinki, Finland aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 365-369 0340-5761 64:5<365 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer