caa a22 4500 467979081 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01973463 doi (NATIONALLICENCE)springer-10.1007/BF01973463 Protein binding, sister chromatid exchange and expression of oncogene proteins in patients treated with cisplatinum ( cis DDP)-based chemotherapy [Elektronische Daten] [F. Perera, H. Fischman, K. Hemminki, P. Brandt-Rauf, H. Niman, S. Smith, E. Toporoff, K. O'Dowd, M. Tang, W. Tsai, M. Stoopler] The aim of this pilot was to evaluate the feasibility of incorporating several complementary biologic markers into a molecular epidemiologic study of chemotherapy patients. Thirty-two cancer patients being treated withcis-DDP-based chemotherapy for the first time were enrolled in the study and donated a baseline sample and at least one post-treatment sample of blood. Sister Chromatid Exchange (SCEs) and plasma protein and hemoglobin binding bycisDDP were significantly increased in samples drawn at various timepoints following treatment. The pattern of nine different oncogene protein products (including those ofras, fes, andmyc) remained unchanged in sera of six patients followed over the course of their treatment. However, the levels ofras P21 product were significantly elevated above normal, control levels in all six cancer patients — both prior to and throughout the course of chemotherapy. These results suggest the usefulness of utilizing a battery of markers to evaluate biologic response to cisplatinum-based chemotherapy. Springer-Verlag, 1990 Carcinogen-protein binding nationallicence Sister chromatid exchange nationallicence Oncogene activation nationallicence Cisplatinum nationallicence Biologic markers nationallicence Perera F. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut Fischman H. Cell Genetics Laboratory, New York State Psychiatric Institute, USA aut Hemminki K. Institute of Occupational Health, Helsinki, Finland aut Brandt-Rauf P. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut Niman H. Progenx Inc., San Diego, Ca., USA aut Smith S. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut Toporoff E. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut O'Dowd K. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut Tang M. Division of Biostatistics, Columbia University School of Public Health, USA aut Tsai W. Division of Biostatistics, Columbia University School of Public Health, USA aut Stoopler M. Columbia University College of Physicians & Surgeons, USA aut Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 401-406 0340-5761 64:5<401 1990 64 204 https://doi.org/10.1007/BF01973463 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01973463 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perera F. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut NATIONALLICENCE 700 1- Fischman H. Cell Genetics Laboratory, New York State Psychiatric Institute, USA aut NATIONALLICENCE 700 1- Hemminki K. Institute of Occupational Health, Helsinki, Finland aut NATIONALLICENCE 700 1- Brandt-Rauf P. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut NATIONALLICENCE 700 1- Niman H. Progenx Inc., San Diego, Ca., USA aut NATIONALLICENCE 700 1- Smith S. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut NATIONALLICENCE 700 1- Toporoff E. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut NATIONALLICENCE 700 1- O'Dowd K. Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Ave, B-109, 10032, NY, NY, USA aut NATIONALLICENCE 700 1- Tang M. Division of Biostatistics, Columbia University School of Public Health, USA aut NATIONALLICENCE 700 1- Tsai W. Division of Biostatistics, Columbia University School of Public Health, USA aut NATIONALLICENCE 700 1- Stoopler M. Columbia University College of Physicians & Surgeons, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 401-406 0340-5761 64:5<401 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer