caa a22 4500 46797909X CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01973458 doi (NATIONALLICENCE)springer-10.1007/BF01973458 Species differences in short term toxicity from inhalation exposure to bromobenzene [Elektronische Daten] [Jon Dahl, Rune Becher, Kjell Aarstad, Odd Nilsen, Erik Dybing] Lung, liver and kidney injury were studied in mice, rats and rabbits 48 h after termination of a 4 h inhalation exposure to bromobenzene vapour (250-3400 ppm). Light and electron microscopy of lung tissue revealed injury to Clara cells and adjacent epithelium in mouse bronchioli (bromobenzene concentration 250 ppm and 1000 ppm) and to Clara cells of rat bronchi and bronchioli (1000 ppm bromobenzene) and of rabbit bronchi (2500 ppm and 3400 ppm). Histological and clinicochemical indices of liver damage were found in the same animals, whereas kidney toxicity was observed in mice (two out of ten showed tubular necrosis and elevated concentration of plasma urea) and rats (all had elevated plasma concentrations of creatinine) exposed to 1000 ppm bromobenzene. Inhalation exposure thus produced less kidney injury than expected from previous studies with equimolar doses given intraperitoneally. The mouse was the most severely affected species, followed by the rat, and lastly the rabbit. The animal susceptibility could not be ranked according to the rate of14C-bromobenzene covalent binding in lung or liver, but it was inversely related to the rate of N-demethylation of benzphetamine (indicative of P450IIB activity) in both lung and liver microsomal preparations. Differences in a P450 mediated detoxification could therefore be of importance in species variability to bromobenzene injury. Springer-Verlag, 1990 Bromobenzenes nationallicence Hydrocarbons nationallicence Lung nationallicence Liver nationallicence Kidney nationallicence Monooxygenases nationallicence Dahl Jon Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, N-0462, Oslo 4, Norway aut Becher Rune Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, N-0462, Oslo 4, Norway aut Aarstad Kjell Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, N-7006, Trondheim, Norway aut Nilsen Odd Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, N-7006, Trondheim, Norway aut Dybing Erik Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, N-0462, Oslo 4, Norway aut Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 370-376 0340-5761 64:5<370 1990 64 204 https://doi.org/10.1007/BF01973458 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01973458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dahl Jon Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, N-0462, Oslo 4, Norway aut NATIONALLICENCE 700 1- Becher Rune Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, N-0462, Oslo 4, Norway aut NATIONALLICENCE 700 1- Aarstad Kjell Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, N-7006, Trondheim, Norway aut NATIONALLICENCE 700 1- Nilsen Odd Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, N-7006, Trondheim, Norway aut NATIONALLICENCE 700 1- Dybing Erik Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, N-0462, Oslo 4, Norway aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 370-376 0340-5761 64:5<370 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer