caa a22 4500 467979227 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF01974400 doi (NATIONALLICENCE)springer-10.1007/BF01974400 Oishi Shinshi Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1, Hyakunincho, Shinjuku-ku, 169, Tokyo, Japan aut Effects of phthalic acid esters on testicular mitochondrial functions in the rat [Elektronische Daten] [Shinshi Oishi] Although it is well established that high dose administration of di(2-ethylhexyl) phthalate (DEHP) and its monoester metabolite (MEHP) induces severe testicular atrophy in rats, the mechanisms of this testicular injury is not clear. The present experiment was undertaken to examine the effects of DEHP and MEHP on mitochondrial functions of rat testis. DEHP and di-n-octyl phthalate (DOP), a DEHP isomer which causes less severe testicular injury, did not inhibit the state 3 oxygen consumption up to 0.65 μmole/ml in vitro. On the other hand, MEHP and mono-n-octyl phthalate (MOP), a metabolite of DOP, inhibited the state 3 oxygen consumption down to a concentration of 0.065 μmole/ml. Testicular mitochondrial respiratory functions of rats administered 2 g/kg DEHP were lower than those of control or DOP-treated rats. These differences were verified by characteristics of pharmacokinetic parameters and testicular concentrations of MEHP and MOP. It may be suggested that a possible mechanism of testicular atrophy induced by DEHP may be due to direct inhibition by MEHP (and partially DEHP) of the respiratory functions of Sertoli cell mitochondria in rat testis. Springer-Verlag, 1990 Di(2-ethylhexyl)phthalate nationallicence Di- n -octyl phthalate nationallicence Mitochondrial respiration nationallicence Monoester metabolites nationallicence Pharmacokinetics nationallicence Testicular atrophy nationallicence Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 143-147 0340-5761 64:2<143 1990 64 204 https://doi.org/10.1007/BF01974400 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974400 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Oishi Shinshi Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1, Hyakunincho, Shinjuku-ku, 169, Tokyo, Japan aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 143-147 0340-5761 64:2<143 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer