caa a22 4500 467979278 CHVBK 20180323112515.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF01974392 doi (NATIONALLICENCE)springer-10.1007/BF01974392 Effect of N-benzyl- d -glucamine dithiocarbamate on renal toxicity induced by cadmium-metallothionein in rats [Elektronische Daten] [Shoji Kojima, Hiroshige Ono, Akihiko Furukawa, Morio Kiyozumi] The effect ofN-benzyl-d-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 μmol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 μmol Cd as Cd-MT/kg) and thereafter they received three injections of BGD (400 μmol/kg) daily for 3 days. Urinary protein concentration and aspartate aminotransferase (AST) activity significantly increased 1 day after Cd-MT treatment and decreased to control levels at 9 days after the treatment. Urinary excretion of glucose and amino acids rose gradually reaching maximum levels 5 days after Cd-MT treatment and returned to the control levels at 9 days. BGD injection significantly reduced the increases in the urinary excretion of protein, AST, glucose and amino acid, which were produced by Cd-MT treatment. Significant increases in urine volume were observed after Cd-MT treatment. BGD injection inhibited the increase in urine volume caused by Cd-MT treatment. A long time interval (12 and 24 h) between the administrations of Cd-MT and BGD resulted in a decreased protective effect of BGD against Cd-MT-induced renal damage. Following Cd-MT injection, the major route of excretion of cadmium (Cd) was via the urine and the kidney was the major site of accumulation of Cd. BGD injection remarkably increased the urinary excretion of Cd, resulting in a significant reduction in the kidney Cd concentration. The results of this study indicate that BGD injection is effective in decreasing the Cd concentration in the kidney, resulting in the protective effect on Cd-MT-induced renal damage. Springer-Verlag, 1990 Cadmium-metallothionein nationallicence Renal damage nationallicence N-Benzyl- d -glucamine dithiocarbamate nationallicence Chelate effect nationallicence Kojima Shoji Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut Ono Hiroshige Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut Furukawa Akihiko Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut Kiyozumi Morio Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 91-96 0340-5761 64:2<91 1990 64 204 https://doi.org/10.1007/BF01974392 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974392 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kojima Shoji Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ono Hiroshige Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut NATIONALLICENCE 700 1- Furukawa Akihiko Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut NATIONALLICENCE 700 1- Kiyozumi Morio Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862, Kumamoto, Japan aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 91-96 0340-5761 64:2<91 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer