caa a22 4500 467979294 CHVBK 20180323112515.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF01974401 doi (NATIONALLICENCE)springer-10.1007/BF01974401 Testicular effects of di- n -butyl phthalate (DBP): Biochemical and histopathological alterations [Elektronische Daten] [S. Srivastava, S. Srivastava, D. Saxena, S. Chandra, P. Seth] Di-n-butyl phthalate (DBP) was administered to young male rats by gavage at the doses of 250, 500 and 1000 mg/kg body weight/day for 15 days. A significant decrease in testes weight was observed at 500 and 1000 mg/kg doses of DBP. Histopathological examination revealed marked degeneration of seminiferous tubules. The activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as sorbitol dehydrogenase and acid phosphatase, were decreased significantly, while that of lactate dehydrogenase was significantly increased, coincident with degeneration of spermatogenic cells. The activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells, β-glucuronidase, γ-glutamyl transpeptidase and glucose-6-phosphate dehydrogenase were significantly increased. Thus the alterations in activity of these testicular cell specific enzymes suggest that DBP exposure during early life could affect the testicular functions. Springer-Verlag, 1990 Di- n -butyl phthalate nationallicence Testes nationallicence Rat nationallicence Toxicity nationallicence Srivastava S. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut Saxena D. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut Chandra S. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut Seth P. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 148-152 0340-5761 64:2<148 1990 64 204 https://doi.org/10.1007/BF01974401 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974401 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Srivastava S. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- Saxena D. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- Chandra S. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- Seth P. Industrial Toxicology Research Centre, M.G. Marg, Post Box 80, 226 001, Lucknow, India aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 148-152 0340-5761 64:2<148 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer