caa a22 4500 467979308 CHVBK 20180323112515.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF01974404 doi (NATIONALLICENCE)springer-10.1007/BF01974404 A mechanism of cadmium poisoning: The cross effect of calcium and cadmium in the calmodulin-dependent system [Elektronische Daten] [Den'etsu Sutoo, Kayo Akiyama, Shunichiro Imamiya] The effects of the intraventricular (IVT) administration of cadmium on the amount of dopamine (DA) in various regions of the mice brain were analyzed immunohistochemically using a microphotometry system. DA levels in the neostriatum and nucleus accumbens were increased by approximately 30% (p<0.01) by the IVT administration of CdCl2 (1 μmol/kg). This effect was abolished by the calmodulin antagonist, W-7 (4.2 μg/mouse, IVT). The effects of cadmium on DA levels in the brain were very similar to those seen with calcium. Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism. Springer-Verlag, 1990 Cadmium nationallicence Calmodulin nationallicence Dopamine nationallicence Neostriatum nationallicence Nucleus accumbens nationallicence Sutoo Den'etsu Institute of Medical Science, University of Tsukuba, Tsukuba, 305, Ibaraki, Japan aut Akiyama Kayo Institute of Medical Science, University of Tsukuba, Tsukuba, 305, Ibaraki, Japan aut Imamiya Shunichiro School of Hygienic Sciences, Kitasato University, Sagamihara, 228, Kanagawa, Japan aut Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 161-164 0340-5761 64:2<161 1990 64 204 https://doi.org/10.1007/BF01974404 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974404 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sutoo Den'etsu Institute of Medical Science, University of Tsukuba, Tsukuba, 305, Ibaraki, Japan aut NATIONALLICENCE 700 1- Akiyama Kayo Institute of Medical Science, University of Tsukuba, Tsukuba, 305, Ibaraki, Japan aut NATIONALLICENCE 700 1- Imamiya Shunichiro School of Hygienic Sciences, Kitasato University, Sagamihara, 228, Kanagawa, Japan aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 161-164 0340-5761 64:2<161 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer