caa a22 4500 467979316 CHVBK 20180323112515.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF01974405 doi (NATIONALLICENCE)springer-10.1007/BF01974405 Changes in urinary n -hexane metabolites by co-exposure to various concentrations of methyl ethyl ketone and fixed n -hexane levels [Elektronische Daten] [E. Shibata, J. Huang, Y. Ono, N. Hisanaga, M. Iwata, I. Saito, Y. Takeuchi] To make clear how then-hexane metabolism is modified by co-exposure with MEK, rats were exposed to various concentrations of MEK mixed with a fixed concentration ofn-hexane. Twenty-four male Wistar rats were divided into four equal groups. Each group was exposed for 8 h to 2000 ppmn-hexane, 2000 ppmn-hexane plus 200 ppm MEK, 2000 ppmn-hexane plus 630 ppm MEK and 2000 ppmn-hexane plus 2000 ppm MEK, respectively. Free metabolites and the sum of free and conjugated metabolites ofn-hexane were analyzed by gas chromatography. The main metabolite was 2-hexanol during the exposure and 2,5-hexanedione (2,5-HD) after the exposure in any group. The main metabolites, 2-hexanol and 2,5 HD, decreased in iverse proportion to the co-exposed MEK concentrations. The results suggest that augmentation ofn-hexane neurotoxicity by MEK co-exposure could not be explained only by 2,5-HD. In addition, 2,5-HD is recommended as an index for biological monitoring ofn-hexane exposure. However, one should be careful to evaluate the exposedn-hexane concentration by urinary 2,5-HD, becausen-hexane metabolism could be largely modified by co-exposure with MEK. Springer-Verlag, 1990 n -Hexane nationallicence Urinary metabolites nationallicence Mixed exposure nationallicence MEK nationallicence Shibata E. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut Huang J. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut Ono Y. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut Hisanaga N. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut Iwata M. Toyota Memorial Hospital, Heiwa-cho, 1-1, 471, Toyota, Japan aut Saito I. Aichi Prefectural Institute of Public Health, Nagare 7-6, Tsujimachi, Kita-ku, 462, Nagoya, Japan aut Takeuchi Y. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 165-168 0340-5761 64:2<165 1990 64 204 https://doi.org/10.1007/BF01974405 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974405 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shibata E. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut NATIONALLICENCE 700 1- Huang J. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut NATIONALLICENCE 700 1- Ono Y. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut NATIONALLICENCE 700 1- Hisanaga N. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut NATIONALLICENCE 700 1- Iwata M. Toyota Memorial Hospital, Heiwa-cho, 1-1, 471, Toyota, Japan aut NATIONALLICENCE 700 1- Saito I. Aichi Prefectural Institute of Public Health, Nagare 7-6, Tsujimachi, Kita-ku, 462, Nagoya, Japan aut NATIONALLICENCE 700 1- Takeuchi Y. Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/2(1990-03-01), 165-168 0340-5761 64:2<165 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer