caa a22 4500 467983380 CHVBK 20180323112524.0 cr unu---uuuuu 170328e19900501xx s 000 0 eng 10.1007/BF00210803 doi (NATIONALLICENCE)springer-10.1007/BF00210803 Cell type-dependent difference in the distribution and frequency of excess thymidine-induced common fragile sites: T lymphocytes and skin fibroblasts [Elektronische Daten] [Akira Kuwano, Ichiro Murano, Tadashi Kajii] Summary: Common fragile sites were induced by excess thymidine in phytohemagglutin-stimulated T lymphocytes from 4 normal individuals, and skin fibroblasts from 4 normal and 5 fra(X) positive individuals. The results indicate that the frequency and distribution of excess thymidine-induced fragile sites are different between these two types of cells. The sites at 1p13 and 2p11.2, induced in both types of cells, have not previously been described, and are thus considered to be excess thymidine-specific fragile sites. These findings extend and support our previous studies on cell type-dependent difference in aphidicolin-induced common fragile sites. Springer-Verlag, 1990 Kuwano Akira Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Japan aut Murano Ichiro Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Japan aut Kajii Tadashi Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Japan aut Human Genetics Springer-Verlag 84/6(1990-05-01), 527-531 0340-6717 84:6<527 1990 84 439 https://doi.org/10.1007/BF00210803 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00210803 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuwano Akira Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Japan aut NATIONALLICENCE 700 1- Murano Ichiro Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Japan aut NATIONALLICENCE 700 1- Kajii Tadashi Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Japan aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/6(1990-05-01), 527-531 0340-6717 84:6<527 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer