caa a22 4500 467983453 CHVBK 20180323112525.0 cr unu---uuuuu 170328e19900501xx s 000 0 eng 10.1007/BF00210804 doi (NATIONALLICENCE)springer-10.1007/BF00210804 Cytogenetic characterization of ataxia telangiectasia (AT) heterozygotes using lymphoblastoid cell lines and chronic γ-irradiation [Elektronische Daten] [Manjula Waghray, Sultan Al-Sedairy, Pinar Ozand, Mohammed Hannan] Summary: Lymphoblastoid cell lines (LCLs) derived from two patients identified as ataxia telangiectasia (AT), two obligate AT heterozygotes and two controls (healthy subjects with no known genetic disease or relationship to AT patients) were compared with respect to the induction of chromosomal breaks by acute and chronic γ-irradiation. Although there was a considerable increase in the frequency of chromosomal breaks per cell in the LCLs of AT patients resulting from acute irradiation, the small increase occurring in the LCLs of the AT heterozygotes made it difficult to distinguish them from the controls. Following chronic γ-irradiation, however, the frequency of chromosomal breaks per cell in the LCLs of the AT heterozygotes occupied a significantly distinct position from that of the controls. These observations suggested that the use of chronic irradiation may be a better choice in the cytogenetic characterization of AT heterozygotes. Springer-Verlag, 1990 Waghray Manjula Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut Al-Sedairy Sultan Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut Ozand Pinar Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut Hannan Mohammed Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut Human Genetics Springer-Verlag 84/6(1990-05-01), 532-534 0340-6717 84:6<532 1990 84 439 https://doi.org/10.1007/BF00210804 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00210804 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Waghray Manjula Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Al-Sedairy Sultan Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Ozand Pinar Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Hannan Mohammed Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/6(1990-05-01), 532-534 0340-6717 84:6<532 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer