caa a22 4500 467983631 CHVBK 20180323112525.0 cr unu---uuuuu 170328e19900201xx s 000 0 eng 10.1007/BF00200577 doi (NATIONALLICENCE)springer-10.1007/BF00200577 Probe, VK5B, is located in the same interval as the autosomal dominant adult polycystic kidney disease locus, PKD1 [Elektronische Daten] [V. Hyland, G. Suthers, K. Friend, R. MacKinnon, D. Callen, M. Breuning, T. Keith, V. Brown, P. Phipps, G. Sutherland] Summary: The polymorphic DNA probe VK5B (D16S94) was mapped by genetic linkage in families from the Centre d'Etude de Polymorphisme Humain (CEPH) as being in the same interval as the autosomal dominant adult polycystic kidney disease locus (PKD1). The maximum likelihood estimate of the genetic location of VK5B using multipoint linkage analysis was 9.6cM proximal to {ie286-01} (D16S85) and 5.4cM distal to CRI-0327 (D16S63), in males. The VK5B probe may be useful in PKD1 families for prenatal and presymptomatic diagnosis of the disease. Additional typing of PKD1 families is required to determine whether the location of VK5B is distal or proximal to (PKD1). Springer-Verlag, 1990 Hyland V. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut Suthers G. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut Friend K. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut MacKinnon R. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut Callen D. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut Breuning M. Institute of Human Genetics, Sylvius Laboratories, University of Leiden, NL-2333, AL Leiden, The Netherlands aut Keith T. Collaborative Research Inc., Two Oak Park, 02139, Bedford, MA, USA aut Brown V. Collaborative Research Inc., Two Oak Park, 02139, Bedford, MA, USA aut Phipps P. Collaborative Research Inc., Two Oak Park, 02139, Bedford, MA, USA aut Sutherland G. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut Human Genetics Springer-Verlag 84/3(1990-02-01), 286-288 0340-6717 84:3<286 1990 84 439 https://doi.org/10.1007/BF00200577 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00200577 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hyland V. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut NATIONALLICENCE 700 1- Suthers G. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut NATIONALLICENCE 700 1- Friend K. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut NATIONALLICENCE 700 1- MacKinnon R. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut NATIONALLICENCE 700 1- Callen D. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut NATIONALLICENCE 700 1- Breuning M. Institute of Human Genetics, Sylvius Laboratories, University of Leiden, NL-2333, AL Leiden, The Netherlands aut NATIONALLICENCE 700 1- Keith T. Collaborative Research Inc., Two Oak Park, 02139, Bedford, MA, USA aut NATIONALLICENCE 700 1- Brown V. Collaborative Research Inc., Two Oak Park, 02139, Bedford, MA, USA aut NATIONALLICENCE 700 1- Phipps P. Collaborative Research Inc., Two Oak Park, 02139, Bedford, MA, USA aut NATIONALLICENCE 700 1- Sutherland G. Cytogenetics Unit, Adelaide Children's Hospital, 5006, North Adelaide, South Australia, Australia aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/3(1990-02-01), 286-288 0340-6717 84:3<286 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer