caa a22 4500 467983658 CHVBK 20180323112525.0 cr unu---uuuuu 170328e19900201xx s 000 0 eng 10.1007/BF00200575 doi (NATIONALLICENCE)springer-10.1007/BF00200575 Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region [Elektronische Daten] [Jingshi Wu, Kenneth Kidd] Summary: Extensive sequence polymorphisms exist in the chromosome 10 alpha satellite DNA (the D10Z1 locus). Polymorphic morphs revealed by the enzymes PstI, EcoRV, and HincII, can be unambiguously scored and make this centromeric region an excellent genetic marker for the study of multiple endocrine neoplasia, type 2A (MEN2A), as well as for chromosome 10 linkage studies in general. Strong positive lod scores and linkage distance relationships between D10Z1 and DNA markers from the chromosome 10 pericentromeric region, especially FNRB and RBP3, known to be on either side of the centromere, provide independent support for mapping of all these loci. Springer-Verlag, 1990 Wu Jingshi Department of Human Genetics, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Kidd Kenneth Department of Human Genetics, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Human Genetics Springer-Verlag 84/3(1990-02-01), 279-282 0340-6717 84:3<279 1990 84 439 https://doi.org/10.1007/BF00200575 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00200575 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Jingshi Department of Human Genetics, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Kidd Kenneth Department of Human Genetics, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/3(1990-02-01), 279-282 0340-6717 84:3<279 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer