caa a22 4500 467983682 CHVBK 20180323112525.0 cr unu---uuuuu 170328e19900201xx s 000 0 eng 10.1007/BF00200579 doi (NATIONALLICENCE)springer-10.1007/BF00200579 Human pepsinogen A (PGA): an informative gene complex located at 11q13 [Elektronische Daten] [Farzin Boudi, Ragnhild Lothe, R. Taggart] Summary: Human pepsinogen (PGA) exhibits extensive polymorphism that can be detected both at the protein and the DNA level. We describe here two restriction fragment length polymorphisms, EcoRI and BglII, which provide for the detection of three of the most common PGA haplotypes (A, B, and C) in the United States population. The relationship of these polymorphisms to each PGA haplotype was determined by analysis of DNA from individuals exhibiting the corresponding protein phenotypes and by analysis of a series of human × mouse somatic cell hybrids containing the individual chromosome 11 homologous from heterozygous individuals exhibiting the AB and AC protein phenotypes. The use of the BglII polymorphism in combination with previously described EcoRI polymorphism provides a very informative marker of 11q13. Springer-Verlag, 1990 Boudi Farzin Department of Molecular Biology and Genetics, Wayne State University School of Medicine, 540 East Canfield, 48201, Detroit, MI, USA aut Lothe Ragnhild Det Norske Radiumhospitalet, Montebello, N-0310, Oslo, Norway aut Taggart R. Department of Molecular Biology and Genetics, Wayne State University School of Medicine, 540 East Canfield, 48201, Detroit, MI, USA aut Human Genetics Springer-Verlag 84/3(1990-02-01), 293-295 0340-6717 84:3<293 1990 84 439 https://doi.org/10.1007/BF00200579 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00200579 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boudi Farzin Department of Molecular Biology and Genetics, Wayne State University School of Medicine, 540 East Canfield, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Lothe Ragnhild Det Norske Radiumhospitalet, Montebello, N-0310, Oslo, Norway aut NATIONALLICENCE 700 1- Taggart R. Department of Molecular Biology and Genetics, Wayne State University School of Medicine, 540 East Canfield, 48201, Detroit, MI, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/3(1990-02-01), 293-295 0340-6717 84:3<293 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer