caa a22 4500 467983755 CHVBK 20180323112525.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF00196233 doi (NATIONALLICENCE)springer-10.1007/BF00196233 Lymphocyte and sperm chromosome studies in cancer-treated men [Elektronische Daten] [A. Genescà, L. Barrios, R. Miró, M. Caballín, J. Benet, C. Fuster, X. Bonfill, J. Egozcue] Summary: To evaluate the reliability of the quantitative extrapolation of the long-term effect of cancer therapies from somatic cells to germ cells, we compared the frenuency of chromosome abnormalities in 303 lymphocytes from four individuals treated with radio- and/or chemotherapy 5-18 years earlier with the frequency in 422 spermatozoa from the same individuals. The mean frequency of structurally abnormal complements was much higher in germ cells than in somatic cells (P = 2.08 × 10−6). The fact that spermatogenic cells share cytoplasm is suggested as a possible factor in the increased viability of germ cells with chromosome aberrations. In addition, in spermatozoa the incidence of structural chromosome abnormalities was much higher in treated individuals than in controls (P < 0.00060), while in lymphocytes no statistically significant differences could be observed. This observation and the apparent lack of relationship between individual frequencies in the two kinds of cells suggest that the long-term effect of antitumor treatments on germ cells cannot be extrapolated from the analysis of somatic cells. Springer-Verlag, 1990 Genescà A. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Barrios L. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Miró R. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Caballín M. Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Benet J. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Fuster C. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Bonfill X. Servei d' Epidemiologia i Informació Clíniques, Hospital de Sabadell, E-08208, Sabadell, Spain aut Egozcue J. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut Human Genetics Springer-Verlag 84/4(1990-03-01), 353-355 0340-6717 84:4<353 1990 84 439 https://doi.org/10.1007/BF00196233 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00196233 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Genescà A. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Barrios L. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Miró R. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Caballín M. Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Benet J. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Fuster C. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 700 1- Bonfill X. Servei d' Epidemiologia i Informació Clíniques, Hospital de Sabadell, E-08208, Sabadell, Spain aut NATIONALLICENCE 700 1- Egozcue J. Departament de Biologia Cel.lular i Fisiologia (Facultat de Medicina), Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/4(1990-03-01), 353-355 0340-6717 84:4<353 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer