caa a22 4500 467983801 CHVBK 20180323112525.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF00196239 doi (NATIONALLICENCE)springer-10.1007/BF00196239 An insertion deletion polymorphism in the signal peptide of the human apolipoprotein B gene [Elektronische Daten] [Sophia Visvikis, Lawrence Chan, Gerard Siest, Pierre Drouin, Eric Boerwinkle] Summary: In this communication we report the genetic properties of an insertion/deletion polymorphism in the signal peptide of the human apolipoprotein B (apo b) gene. There are two alleles of the apo B signal peptide; one codes for a peptide 27 amino acids in length and the other a peptide only 24 amino acids in length. Using the polymerase chain reaction the difference of nine nucleotides between the two alleles is readily detectable after electrophoresis of the amplification products. The relative frequencies of the Ins and Del alleles are 0.655 and 0.345, respectively. The apo B signal peptide genotypes are transmitted in a manner consistent with an autosomal codominant mode of inheritance with two alleles. Springer-Verlag, 1990 Visvikis Sophia Center for Preventive Medicine, U.A. CNRS 597, F-54501, Vandoeuvre-les-Nancy, France aut Chan Lawrence Departments of Cell Biology and Medicine, Baylor College of Medicine, 77030, Houston, TX, USA aut Siest Gerard Center for Preventive Medicine, U.A. CNRS 597, F-54501, Vandoeuvre-les-Nancy, France aut Drouin Pierre Medical Services G, Jeanne d'Arc Hospital, F-54200, Dommartin-les-Toul, France aut Boerwinkle Eric Center for Demographic and Population Genetics, The University of Texas Health Science Center in Houston, 77225, Houston, TX, USA aut Human Genetics Springer-Verlag 84/4(1990-03-01), 373-375 0340-6717 84:4<373 1990 84 439 https://doi.org/10.1007/BF00196239 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00196239 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Visvikis Sophia Center for Preventive Medicine, U.A. CNRS 597, F-54501, Vandoeuvre-les-Nancy, France aut NATIONALLICENCE 700 1- Chan Lawrence Departments of Cell Biology and Medicine, Baylor College of Medicine, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Siest Gerard Center for Preventive Medicine, U.A. CNRS 597, F-54501, Vandoeuvre-les-Nancy, France aut NATIONALLICENCE 700 1- Drouin Pierre Medical Services G, Jeanne d'Arc Hospital, F-54200, Dommartin-les-Toul, France aut NATIONALLICENCE 700 1- Boerwinkle Eric Center for Demographic and Population Genetics, The University of Texas Health Science Center in Houston, 77225, Houston, TX, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/4(1990-03-01), 373-375 0340-6717 84:4<373 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer