caa a22 4500 46798381X CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF00196231 doi (NATIONALLICENCE)springer-10.1007/BF00196231 Frequency and effect of human apolipoprotein A-IV polymorphism on lipid and lipoprotein levels in an Icelandic population [Elektronische Daten] [Hans-Jürgen Menzel, Gunnar Sigurdsson, Eric Boerwinkle, Silvia Schrangl-Will, Hans Dieplinger, Gerd Utermann] Summary: Human apolipoprotein A-IV (apo A-IV) exhibits a genetic polymorphism with two common alleles, A-IV1 and A-IV2, in Caucasian populations. We have investigated this polymorphism in the Icelandic population. The frequencies of the two alleles are significantly different from middel European populations with a higher frequency of the A-IV2 allele (0.117 versus 0.077) occurring in Iceland. The alleles at the apo A-IV locus have significant effects on plasma high density lipoprotein cholesterol (HDL-C) and triglyceride levels. The average effect of the A-IV2 allele is to raise HDL-C by 4.9 mg/dl and to lower triglyceride levels by 19.4mg/dl. We estimate that the genetic variability at the apo A-IV gene locus accounts for 3.1% of the total variability of HDL-C and for 2.8% of the total variability of triglycerides in the population from Iceland. This confirms and extends our previous observations on apo A-IV allele effects in Tyroleans in an independent population. Springer-Verlag, 1990 Menzel Hans-Jürgen Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut Sigurdsson Gunnar Reykjavik City Hospital, 108, Reykjavik, Iceland aut Boerwinkle Eric Center for Demographic and Population Genetics, University of Texas Health Science Center at Houston, 77225, Houston, TX, USA aut Schrangl-Will Silvia Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut Dieplinger Hans Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut Utermann Gerd Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut Human Genetics Springer-Verlag 84/4(1990-03-01), 344-346 0340-6717 84:4<344 1990 84 439 https://doi.org/10.1007/BF00196231 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00196231 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Menzel Hans-Jürgen Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Sigurdsson Gunnar Reykjavik City Hospital, 108, Reykjavik, Iceland aut NATIONALLICENCE 700 1- Boerwinkle Eric Center for Demographic and Population Genetics, University of Texas Health Science Center at Houston, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Schrangl-Will Silvia Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Dieplinger Hans Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Utermann Gerd Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/4(1990-03-01), 344-346 0340-6717 84:4<344 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer