caa a22 4500 467983836 CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900301xx s 000 0 eng 10.1007/BF00196237 doi (NATIONALLICENCE)springer-10.1007/BF00196237 Genetic studies on human thyroxine-binding globulin (TBG) [Elektronische Daten] [C. Luckenbach, J. Kömpf, H. Ritter] Summary: An enzyme immunoassay technique combined with Western blotting is described to demonstrate thyroxine-binding globulin (TBG) by isoelectric focusing in thin-layer polyacrylamide gels with 8mol/l urea. Quantitative evaluation was by laser densitometry. No genetic charge variants of TBG were encountered in a sample of 840 unrelated individuals from southwestern Germany. There was no correlation between structural and quantitative variations in the TBG protein. Results from a family with quantitative TBG deficiency strongly support the postulated X-linked mode of inheritance. The method described can be considered as an additional diagnostic tool in thyroid evaluation. Springer-Verlag, 1990 Luckenbach C. Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Germany aut Kömpf J. Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Germany aut Ritter H. Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Germany aut Human Genetics Springer-Verlag 84/4(1990-03-01), 368-370 0340-6717 84:4<368 1990 84 439 https://doi.org/10.1007/BF00196237 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00196237 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luckenbach C. Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Germany aut NATIONALLICENCE 700 1- Kömpf J. Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Germany aut NATIONALLICENCE 700 1- Ritter H. Institut für Anthropologie und Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/4(1990-03-01), 368-370 0340-6717 84:4<368 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer