caa a22 4500 467983860 CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900401xx s 000 0 eng 10.1007/BF00195804 doi (NATIONALLICENCE)springer-10.1007/BF00195804 Viral integration, fragile sites, and proto-oncogenes in human neoplasia [Elektronische Daten] [Nicholas Popescu, Drazen Zimonjic, Joseph DiPaolo] Summary: To evaluate the trend of viral integration in the human genome, chromosomal localization of five DNA-containing viruses compiled from literature data was compared to the location of fragile sites and protooncogenes. A total of 35 regionally mapped viral integration sites from tumors and transformed cells were distributed over 19 chromosomes. Of the 35 integration sites 23 (66%) were at the bands of fragile sites, and 7 were one band away (20%). This statistically defines the correlation as highly significant (P = 0.0000183, Fisher's F-test). Five integration sites did not correspond to the location of a fragile site. Thirteen integration sites and proto-oncogenes mapped at the same bands (37%), 6. (17%) were one band apart, and at 16 integration sites (46%) no proto-oncogenes were localized (P = 0.00491). Eighteen viral integration sites, fragile sites, and protooncogenes (51%) were localized at the same bands or one band distant. This clustering of viral integration sites, fragile sites, and proto-oncogenes is statistically highly significant (P = 0.0000118), and indicates nonrandom viral integration in the human genome. Springer-Verlag, 1990 Popescu Nicholas Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute, Bldg. 37 — Room 2A19, 20892, Bethesda, MD, USA aut Zimonjic Drazen Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Yugoslavia aut DiPaolo Joseph Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute, Bldg. 37 — Room 2A19, 20892, Bethesda, MD, USA aut Human Genetics Springer-Verlag 84/5(1990-04-01), 383-386 0340-6717 84:5<383 1990 84 439 https://doi.org/10.1007/BF00195804 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195804 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Popescu Nicholas Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute, Bldg. 37 — Room 2A19, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Zimonjic Drazen Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Yugoslavia aut NATIONALLICENCE 700 1- DiPaolo Joseph Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute, Bldg. 37 — Room 2A19, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/5(1990-04-01), 383-386 0340-6717 84:5<383 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer