caa a22 4500 467983925 CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900401xx s 000 0 eng 10.1007/BF00195823 doi (NATIONALLICENCE)springer-10.1007/BF00195823 The human homeobox gene HOX7 maps to chromosome 4p16.1 and may be implicated in Wolf-Hirschhorn syndrome [Elektronische Daten] [Alasdair Ivens, Nora Flavin, Robert Williamson, Michael Dixon, Gillian Bates, Margaret Buckingham, Benoit Robert] Summary: A cosmid containing the human sequence (HOX7) homologous to the mouse homeogene Hox-7 was isolated from a genomic cosmid library. There is only one highly conserved homologous gene in the human genome. The C-terminal two-thirds of the HOX7 homeobox DNA sequence has been determined; there are no predicted amino acid changes from the mouse sequence. Data from mouse/human hybrid cell lines show that HOX7 maps to human chromosome 4p16.1, a region that is syntenic with part of mouse chromosome 5, the site of the murine Hox-7 gene. Analysis of chromosomes from two patients with Wolf-Hirschhorn syndrome, which is characterised by profound dysmorphologies, indicates that the HOX7 locus is deleted. Although not all Wolf-Hirschhorn syndrome patients analysed were deleted for HOX7, the combination of positional data and functional correlation with mouse expression implicates HOX7 as a candidate gene for this syndrome. Springer-Verlag, 1990 Ivens Alasdair Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut Flavin Nora Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut Williamson Robert Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut Dixon Michael Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut Bates Gillian Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2, London, UK aut Buckingham Margaret Institut Pasteur, 25 Rue du Dr. Roux, F-75015, Paris, France aut Robert Benoit Institut Pasteur, 25 Rue du Dr. Roux, F-75015, Paris, France aut Human Genetics Springer-Verlag 84/5(1990-04-01), 473-476 0340-6717 84:5<473 1990 84 439 https://doi.org/10.1007/BF00195823 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195823 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ivens Alasdair Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Flavin Nora Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Williamson Robert Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Dixon Michael Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, W2 1PG, London, UK aut NATIONALLICENCE 700 1- Bates Gillian Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2, London, UK aut NATIONALLICENCE 700 1- Buckingham Margaret Institut Pasteur, 25 Rue du Dr. Roux, F-75015, Paris, France aut NATIONALLICENCE 700 1- Robert Benoit Institut Pasteur, 25 Rue du Dr. Roux, F-75015, Paris, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/5(1990-04-01), 473-476 0340-6717 84:5<473 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer