caa a22 4500 467984018 CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900401xx s 000 0 eng 10.1007/BF00195806 doi (NATIONALLICENCE)springer-10.1007/BF00195806 Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers [Elektronische Daten] [Emilio Donti, Luisa Lanfrancone, Kay Huebner, Anna Pascucci, Giovanna Venti, Gina Pengue, Fausto Grignani, Carlo Croce, Luigi Lania, Pier Pelicci] Summary: The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer. Springer-Verlag, 1990 Donti Emilio Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut Lanfrancone Luisa Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut Huebner Kay Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 19140, Philadelphia, PA, USA aut Pascucci Anna Dipartimento di Genetica, Università di Napoli, I-80134, Naples, Italy aut Venti Giovanna Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut Pengue Gina Dipartimento di Genetica, Università di Napoli, I-80134, Naples, Italy aut Grignani Fausto Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut Croce Carlo Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 19140, Philadelphia, PA, USA aut Lania Luigi Dipartimento di Genetica, Università di Napoli, I-80134, Naples, Italy aut Pelicci Pier Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut Human Genetics Springer-Verlag 84/5(1990-04-01), 391-395 0340-6717 84:5<391 1990 84 439 https://doi.org/10.1007/BF00195806 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195806 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Donti Emilio Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Lanfrancone Luisa Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Huebner Kay Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Pascucci Anna Dipartimento di Genetica, Università di Napoli, I-80134, Naples, Italy aut NATIONALLICENCE 700 1- Venti Giovanna Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Pengue Gina Dipartimento di Genetica, Università di Napoli, I-80134, Naples, Italy aut NATIONALLICENCE 700 1- Grignani Fausto Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Croce Carlo Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Lania Luigi Dipartimento di Genetica, Università di Napoli, I-80134, Naples, Italy aut NATIONALLICENCE 700 1- Pelicci Pier Istituto di Clinica Medica I, Policlinico Monteluce, Università di Perugia, I-06100, Perugia, Italy aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/5(1990-04-01), 391-395 0340-6717 84:5<391 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer