caa a22 4500 467984085 CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900401xx s 000 0 eng 10.1007/BF00195822 doi (NATIONALLICENCE)springer-10.1007/BF00195822 A Pvu II restriction fragment length polymorphism of the glucose-6-phosphate dehydrogenase gene is an African-specific marker [Elektronische Daten] [Martin Fey, Jim Wainscoat, E. Mukwala, A. Falusi, Tom Vulliamy, Lucio Luzzatto] Summary: The site of a PvuII restriction fragment length polymorphism (RFLP) of the human glucose-6-phosphate dehydrogenase (G6PD) gene has been located in intron V, 60 bp upstream of G6PD exon VI. A population survey shows this RFLP to be specific for African populations, with frequencies of the rarer allele (PvuII type 2 site present) of 0.32-0.40 in Kenyans, Nigerians, Zambians, and West Indians. This allele has not been found in the European, Asian and Middle Eastern populations studied. Such population-specific markers may be useful in the study of population affinities and may provide insight into prehistoric migrations of peoples. Springer-Verlag, 1990 Fey Martin Department of Haematology, John Radcliffe Hospital, Oxford, UK aut Wainscoat Jim Department of Haematology, John Radcliffe Hospital, Oxford, UK aut Mukwala E. Tropical Diseases Centre, Ndola, Zambia aut Falusi A. Postgraduate Institute of Medical Research, University of Ibadan, Ibadan, Nigeria aut Vulliamy Tom Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12, London, ONN, UK aut Luzzatto Lucio Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12, London, ONN, UK aut Human Genetics Springer-Verlag 84/5(1990-04-01), 471-472 0340-6717 84:5<471 1990 84 439 https://doi.org/10.1007/BF00195822 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195822 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fey Martin Department of Haematology, John Radcliffe Hospital, Oxford, UK aut NATIONALLICENCE 700 1- Wainscoat Jim Department of Haematology, John Radcliffe Hospital, Oxford, UK aut NATIONALLICENCE 700 1- Mukwala E. Tropical Diseases Centre, Ndola, Zambia aut NATIONALLICENCE 700 1- Falusi A. Postgraduate Institute of Medical Research, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Vulliamy Tom Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12, London, ONN, UK aut NATIONALLICENCE 700 1- Luzzatto Lucio Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12, London, ONN, UK aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/5(1990-04-01), 471-472 0340-6717 84:5<471 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer