caa a22 4500 467984131 CHVBK 20180323112526.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF00208930 doi (NATIONALLICENCE)springer-10.1007/BF00208930 A "new” genetic polymorphism of a human serum protein: inter-alpha-trypsin-inhibitor [Elektronische Daten] [Ulrike Vogt, Hartwig Cleve] Summary: A new genetic polymorphism of a human serum glycoprotein, the inter-α-trypsin-inhibitor (ITI), has been demonstrated by population and family studies. Sera were examined after neuraminidase treatment by isoelectric focusing on agarose gels followed by immunoblotting or by immunfixation with specific ITI-antiserum. Using this method, three common ITI phenotypes 1, 1-2 and 2, as well as two further rare ITI types 1-3 and 2-3 were disclosed. Genetically, these phenotypes are controlled by three allelic genes that determine a total of six phenotypes. These alleles are designated ITI*1, ITI*2 and ITI*3. The homozygous form of the third allele ITI*3 has not been found, as yet. The frequencies of ITI were examined in two population samples from Southern Germany (n=248) and from Tyrol, Austria (n=124). The gene frequencies of the common alleles ITI*1 and ITI*2 were 0.575 and 0.417, respectively, in Southern Germany, and 0.577 and 0.423, respectively, in Tyrol, Austria. The third allele ITI*3 was found only in the sample from Southern Germany, thus far, and was calculated to be 0.008. Springer-Verlag, 1990 Vogt Ulrike Institut für Anthropologie und Humangenetik der Universität, Richard-Wagner-Strasse 10/I, D-8000, München, 2, Germany aut Cleve Hartwig Institut für Anthropologie und Humangenetik der Universität, Richard-Wagner-Strasse 10/I, D-8000, München, 2, Germany aut Human Genetics Springer-Verlag 84/2(1990-01-01), 151-154 0340-6717 84:2<151 1990 84 439 https://doi.org/10.1007/BF00208930 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00208930 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vogt Ulrike Institut für Anthropologie und Humangenetik der Universität, Richard-Wagner-Strasse 10/I, D-8000, München, 2, Germany aut NATIONALLICENCE 700 1- Cleve Hartwig Institut für Anthropologie und Humangenetik der Universität, Richard-Wagner-Strasse 10/I, D-8000, München, 2, Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/2(1990-01-01), 151-154 0340-6717 84:2<151 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer