caa a22 4500 467984190 CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF00208931 doi (NATIONALLICENCE)springer-10.1007/BF00208931 Parental age and seasonal variation in the births of children with sporadic retinoblastoma: a mutation-epidemiologic study [Elektronische Daten] [E. Matsunaga, K. Minoda, M. Sasaki] Summary: Statistical analysis of parental age data from 225 sporadic cases of bilateral retinoblastoma, plus ten sporadic cases of chromosome deletion or translocation involving 13q14 that was identified as of paternal origin, revealed no evidence of paternal or maternal age effect. Parental exposure to ionizing radiation or chemical mutagens, the effect of which is accumulated with advancing age, does not seem to play a major role in the production of germinal mutations at the responsible (RB) locus. Furthermore, analysis of variation in the month of birth of 753 children with sporadic unilateral retinoblastoma did not show any significant deviation from the controls or a cyclic trend. The occurrence of nonheritable retinoblastoma is not likely to be associated with certain viruses such as human adenovirus 12 whose activity varies markedly with season. These results, together with the fairly uniform pattern in the incidence of this tumor among different populations, suggest that most, if not all, cases of sporadic retinoblastoma are caused by some intrinsic biological mechanisms, and not by environmental mutagens that may vary with respect to time and place. Springer-Verlag, 1990 Matsunaga E. National Institute of Genetics, 411, Mishima, Japan aut Minoda K. Ichihara Hospital, Teikyo University, 229-01, Ichihara, Japan aut Sasaki M. Radiation Biology Center, Kyoto University, 606, Kyoto, Japan aut Human Genetics Springer-Verlag 84/2(1990-01-01), 155-158 0340-6717 84:2<155 1990 84 439 https://doi.org/10.1007/BF00208931 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00208931 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsunaga E. National Institute of Genetics, 411, Mishima, Japan aut NATIONALLICENCE 700 1- Minoda K. Ichihara Hospital, Teikyo University, 229-01, Ichihara, Japan aut NATIONALLICENCE 700 1- Sasaki M. Radiation Biology Center, Kyoto University, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/2(1990-01-01), 155-158 0340-6717 84:2<155 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer