caa a22 4500 467984239 CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF00208929 doi (NATIONALLICENCE)springer-10.1007/BF00208929 Regional assignment of 41 human DNA fragments on chromosome 7 by means of a somatic cell hybrid panel [Elektronische Daten] [Anke Jobs, Dirk Klein-Bölting, Almuth-Sigrun Jandel, Albert Driesel, Klaus Olek, Karl-Heinz Grzeschik] Summary: To detect new restriction fragment length polymorphisms that would cover human chromosome 7 with a network of genetic landmarks, a chromosome 7-specific phage gene library was screened for human single-copy fragments. With use of a somatic cell hybrid panel containing defined regions of human chromosome 7, 41 cloned human single-copy sequences were assigned to five regions of this chromosome. Of special importance are the cell hybrid clones GM1059Rag5 and 7851Rag10-1, derived from human cells with interstitial deletions spanning the bands 7q22-q32, within which the cystic fibrosis gene is located. Twelve new probes are described in 7q22-q32, five of which detect a total of six RFLPs. Springer-Verlag, 1990 Jobs Anke Institut für Humangenetik der Universität, Bahnhofstrasse 7a, D-3550, Marburg, Germany aut Klein-Bölting Dirk Institut für Biochemie der Pflanzen, Hindenburgplatz 55, D-4400, Münster, Germany aut Jandel Almuth-Sigrun Institut für Humangenetik der Universität, Vesaliusweg 12-14, D-4400, Münster, Germany aut Driesel Albert Dechema Institut Frankfurt, Theodor Heuss-Allee 25, D-6000, Frankfurt, Germany aut Olek Klaus Institut für Klinische Biochemie der Universität, Sigmund-Freud-Strasse 15, D-5300, Bonn, 1, Germany aut Grzeschik Karl-Heinz Institut für Humangenetik der Universität, Bahnhofstrasse 7a, D-3550, Marburg, Germany aut Human Genetics Springer-Verlag 84/2(1990-01-01), 147-150 0340-6717 84:2<147 1990 84 439 https://doi.org/10.1007/BF00208929 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00208929 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jobs Anke Institut für Humangenetik der Universität, Bahnhofstrasse 7a, D-3550, Marburg, Germany aut NATIONALLICENCE 700 1- Klein-Bölting Dirk Institut für Biochemie der Pflanzen, Hindenburgplatz 55, D-4400, Münster, Germany aut NATIONALLICENCE 700 1- Jandel Almuth-Sigrun Institut für Humangenetik der Universität, Vesaliusweg 12-14, D-4400, Münster, Germany aut NATIONALLICENCE 700 1- Driesel Albert Dechema Institut Frankfurt, Theodor Heuss-Allee 25, D-6000, Frankfurt, Germany aut NATIONALLICENCE 700 1- Olek Klaus Institut für Klinische Biochemie der Universität, Sigmund-Freud-Strasse 15, D-5300, Bonn, 1, Germany aut NATIONALLICENCE 700 1- Grzeschik Karl-Heinz Institut für Humangenetik der Universität, Bahnhofstrasse 7a, D-3550, Marburg, Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/2(1990-01-01), 147-150 0340-6717 84:2<147 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer