caa a22 4500 467984255 CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF00208938 doi (NATIONALLICENCE)springer-10.1007/BF00208938 Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily [Elektronische Daten] [William Modi, Michael Dean, Hector Seuanez, Naofumi Mukaida, Kouji Matsushima, Stephen O'Brien] Summary: Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals. Springer-Verlag, 1990 Modi William Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility, 21701, Frederick, MD, USA aut Dean Michael Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility, 21701, Frederick, MD, USA aut Seuanez Hector Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701, Frederick, MD, USA aut Mukaida Naofumi Laboratory of Molecular Immunoregulation, National Cancer Institute, 21701, Frederick, MD, USA aut Matsushima Kouji Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701, Frederick, MD, USA aut O'Brien Stephen Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701, Frederick, MD, USA aut Human Genetics Springer-Verlag 84/2(1990-01-01), 185-187 0340-6717 84:2<185 1990 84 439 https://doi.org/10.1007/BF00208938 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00208938 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Modi William Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility, 21701, Frederick, MD, USA aut NATIONALLICENCE 700 1- Dean Michael Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility, 21701, Frederick, MD, USA aut NATIONALLICENCE 700 1- Seuanez Hector Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701, Frederick, MD, USA aut NATIONALLICENCE 700 1- Mukaida Naofumi Laboratory of Molecular Immunoregulation, National Cancer Institute, 21701, Frederick, MD, USA aut NATIONALLICENCE 700 1- Matsushima Kouji Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701, Frederick, MD, USA aut NATIONALLICENCE 700 1- O'Brien Stephen Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701, Frederick, MD, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/2(1990-01-01), 185-187 0340-6717 84:2<185 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer