caa a22 4500 467984301 CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF00208936 doi (NATIONALLICENCE)springer-10.1007/BF00208936 Dual genotype in cutaneous T-cell lymphomas and pseudolymphomas [Elektronische Daten] [Y. Bignon, P. Souteyrand, H. Roger, D. Bernard, B. Dastugue, F. Ramos, M. d'Incan, P. Chollet, R. Plagne] Summary: Genomic DNA digests of skin biopsies from 20 patients with cutaneous T-cell lymphomas and pseudolymphomas were studied by hybridization, using probes for the constant region of the T-cell receptor beta chain and the joining region of the immunoglobin heavy chain gene. Skin biopsies from all 20 patients contained a monoclonal T-cell population. In addition, DNA from 5 patients contained an immunoglobulin gene rearrangement. These results demonstrate that cutaneous T-cell lymphomas are clonal T-cell malignancies that frequently express a dual genotype, which may sometimes reflect the clonotypic heterogeneity of these disorders. Springer-Verlag, 1990 Bignon Y. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut Souteyrand P. Service de Dermatologie, Hôtel-Dieu, F-63000, Clermont-Ferrand, France aut Roger H. Service de Dermatologie, Hôtel-Dieu, F-63000, Clermont-Ferrand, France aut Bernard D. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut Dastugue B. Laboratoire de Biochimie Médicale, Faculté de Médecine, CJF no. 88.06 INSERM, F-63000, Clermont-Ferrand, France aut Ramos F. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut d'Incan M. Laboratoire de Biochimie Médicale, Faculté de Médecine, CJF no. 88.06 INSERM, F-63000, Clermont-Ferrand, France aut Chollet P. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut Plagne R. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut Human Genetics Springer-Verlag 84/2(1990-01-01), 177-178 0340-6717 84:2<177 1990 84 439 https://doi.org/10.1007/BF00208936 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00208936 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bignon Y. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut NATIONALLICENCE 700 1- Souteyrand P. Service de Dermatologie, Hôtel-Dieu, F-63000, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Roger H. Service de Dermatologie, Hôtel-Dieu, F-63000, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Bernard D. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut NATIONALLICENCE 700 1- Dastugue B. Laboratoire de Biochimie Médicale, Faculté de Médecine, CJF no. 88.06 INSERM, F-63000, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Ramos F. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut NATIONALLICENCE 700 1- d'Incan M. Laboratoire de Biochimie Médicale, Faculté de Médecine, CJF no. 88.06 INSERM, F-63000, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Chollet P. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut NATIONALLICENCE 700 1- Plagne R. Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, B.P. 392, F-63011, Clermont-Ferrand Cedex, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/2(1990-01-01), 177-178 0340-6717 84:2<177 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer