caa a22 4500 467984336 CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900101xx s 000 0 eng 10.1007/BF00208927 doi (NATIONALLICENCE)springer-10.1007/BF00208927 An association between α1-antitrypsin phenotype and chronic liver disease [Elektronische Daten] [Yosuke Kishimoto, Sadako Yamada, Chisato Hirayama] Summary: The phenotypes of alpha-1-antitrypsin have been analyzed by isoelectric focusing on polyacrylamide gels in 232 healthy Japanese blood donors and in 240 Japanese patients with chronic liver diseases: 69 with chronic active hepatitis, 122 with liver cirrhosis, 41 with hepatocellular carcinoma and 8 with primary biliary cirrhosis. The liver cirrhosis patients had a gene frequency of 0.07 forPI * M3, which was significantly higher (P<0.01) than that (0.03) in blood donors. The gene frequency of PI * M3 was significantly increased in cryptogenic liver cirrhosis (P<0.05), and there was a tendency toward an increased frequency of PI * M3 in post-transfusion groups, and in primary biliary cirrhosis. There were also tendenciestoward increased frequencies of PI * M3 in cryptogenic and post-transfusion groups of patients with chronic active hepatitis. The present study indicates that PI * M3 is a genetic or predisposing factor for chronic liver diseases, especially for cryptogenic and/or non A-non B viral chronic liver disease and also for primary biliary cirrhosis. Springer-Verlag, 1990 Kishimoto Yosuke Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan aut Yamada Sadako Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan aut Hirayama Chisato Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan aut Human Genetics Springer-Verlag 84/2(1990-01-01), 132-136 0340-6717 84:2<132 1990 84 439 https://doi.org/10.1007/BF00208927 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00208927 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kishimoto Yosuke Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Yamada Sadako Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Hirayama Chisato Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 84/2(1990-01-01), 132-136 0340-6717 84:2<132 1990 84 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer