caa a22 4500 467984433 CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276328 doi (NATIONALLICENCE)springer-10.1007/BF00276328 Inv(14) with distal breakpoint in 14q32.1 in three cases of T cell lymphoma [Elektronische Daten] [Brigitte Schlegelberger, Alfred Feller, Hans-Heinrich Wacker, Jürgen Lohmeyer, Werner Grote] Summary: The distal breakpoint of inv(14) in T cell clones, established from patients with ataxia telangiectasia, lies outside the immunoglobulin heavy chain gene locus on 14q32.3, and more proximal to the centromere than the distal breakpoint of inv(14) in the T cell lymphoma cell line SUP-T1. We report 3 cases of T cell lymphoma cytogenetically showing the same type of inv(14) as the AT T cell clones. All 3 cases express a similar immunophenotype, which is that of peripheral T lymphocytes with phenotypic remnants of thymic or postthymic lymphoblasts. This finding provides evidence that this type of inv(14) is involved in the malignant transformation of mature T lymphocytes. Springer-Verlag, 1990 Schlegelberger Brigitte Abteilung Humangenetik, Zentrum Konservative Medizin II der Christian Albrechts-Universität, Schwanenweg 24, D-2300, Kiel, Federal Republic of Germany aut Feller Alfred Pathologisches Institut der Universität, Josef Schneider-Strasse 2, D-8700, Würzburg, Federal Republic of Germany aut Wacker Hans-Heinrich Abteilung Allgemeine Pathologie und pathologische Anatomie, Zentrum Klinisch-Theoretische Medizin I der Christian Albrechts-Universität, Michaelisstrasse 11, D-2300, Kiel, Federal Republic of Germany aut Lohmeyer Jürgen Abteilung Hämatologie, Zentrum für Innere Medizin der Universität, Klinikstrasse 36, D-6300, Giessen, Federal Republic of Germany aut Grote Werner Abteilung Humangenetik, Zentrum Konservative Medizin II der Christian Albrechts-Universität, Schwanenweg 24, D-2300, Kiel, Federal Republic of Germany aut Human Genetics Springer-Verlag 85/1(1990-06-01), 80-84 0340-6717 85:1<80 1990 85 439 https://doi.org/10.1007/BF00276328 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276328 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schlegelberger Brigitte Abteilung Humangenetik, Zentrum Konservative Medizin II der Christian Albrechts-Universität, Schwanenweg 24, D-2300, Kiel, Federal Republic of Germany aut NATIONALLICENCE 700 1- Feller Alfred Pathologisches Institut der Universität, Josef Schneider-Strasse 2, D-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Wacker Hans-Heinrich Abteilung Allgemeine Pathologie und pathologische Anatomie, Zentrum Klinisch-Theoretische Medizin I der Christian Albrechts-Universität, Michaelisstrasse 11, D-2300, Kiel, Federal Republic of Germany aut NATIONALLICENCE 700 1- Lohmeyer Jürgen Abteilung Hämatologie, Zentrum für Innere Medizin der Universität, Klinikstrasse 36, D-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Grote Werner Abteilung Humangenetik, Zentrum Konservative Medizin II der Christian Albrechts-Universität, Schwanenweg 24, D-2300, Kiel, Federal Republic of Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 80-84 0340-6717 85:1<80 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer