caa a22 4500 46798445X CHVBK 20180323112527.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276325 doi (NATIONALLICENCE)springer-10.1007/BF00276325 Pellestor Franck Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, F-38700, La Tronche, France aut Analysis of meiotic segregation in a man heterozygous for a 13;15 Robertsonian translocation and a review of the literature [Elektronische Daten] [Franck Pellestor] Summary: Meiotic segregation was studied in a male heterozygous for a 13;15 Robertsonian translocation using in vitro sperm penetration of hamster eggs. Sixty-seven sperm chromosome complements were obtained and R-banded. Alternate segregation produced equal numbers of normal (31) and balanced (29) gametes, as was theoretically expected. Incidence of unbalanced complements was 10.4%, and the frequency of abnormalities unrelated to the translocation was 7.4%. This study confirms the predominance of alternate meiotic segregation in Robertsonian translocation carriers. Four sperm studies of Robertsonian translocation have been previously reported. A review of the combined results points out the low incidence of imbalance in the sperm of Robertsonian translocation carrier and the lack of evidence for an interchromosomal effect. Springer-Verlag, 1990 Human Genetics Springer-Verlag 85/1(1990-06-01), 49-54 0340-6717 85:1<49 1990 85 439 https://doi.org/10.1007/BF00276325 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276325 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pellestor Franck Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, F-38700, La Tronche, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 49-54 0340-6717 85:1<49 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer