caa a22 4500 46798459X CHVBK 20180323112528.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276342 doi (NATIONALLICENCE)springer-10.1007/BF00276342 Mediterranean types of β-thalassemia in the German population [Elektronische Daten] [Marion Laig, Michael Pape, Joachim Hundrieser, Gebhard Flatz] Summary: Forty β-thalassemia genes from unrelated German heterozygotes with no known foreign ancestry were examined using the oligonucleotide technique and DNA restriction analysis, with the aim of determining the contribution of Mediterranean β-thalassemia mutations to the prevalence of this trait in the German population. Of the 40 β-thalassemia genes, 26 were identified as Mediterranean types (20 β39 nonsense, 3 IVS2 nt 110, 2 IVS2 nt1, 1 IVS1 ntl G→A). The geographic distribution of the birthplaces of the probands' grandparents revealed no difference in the proportion of Mediterranean and unidentified β-thalassemia genes in the west and the north of Germany. Springer-Verlag, 1990 Laig Marion Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut Pape Michael Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut Hundrieser Joachim Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut Flatz Gebhard Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut Human Genetics Springer-Verlag 85/1(1990-06-01), 135-137 0340-6717 85:1<135 1990 85 439 https://doi.org/10.1007/BF00276342 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Laig Marion Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut NATIONALLICENCE 700 1- Pape Michael Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hundrieser Joachim Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut NATIONALLICENCE 700 1- Flatz Gebhard Abteilung Humangenetik, Medizinische Hochschule, Postfach 61 01 80, D-3000, 61, Hannover, Federal Republic of Germany aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 135-137 0340-6717 85:1<135 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer