caa a22 4500 46798462X CHVBK 20180323112528.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276317 doi (NATIONALLICENCE)springer-10.1007/BF00276317 Linkage between a PvuII restriction fragment length polymorphism and G6PD A-202A/376G: evidence for a single origin of the common G6PD A — mutation [Elektronische Daten] [Ernest Beutler, Wanda Kuhl] Summary: DNA samples from 29 males with the G6PD A-phenotype and 14 males with a G6PD B phenotype were studied for the presence of each of four polymorphic restriction sites in the glucose-6-phosphate dehydrogenase locus. All G6PD A-subjects with the G6PD A-202A/376G genotype, regardless of population origin, shared identical haplotypes. In view of the fact that at least one of the restriction sites, the PvuII site in the intron between exon 5 and 6, has thus far been uncommon in the populations studied, it seems likely that the G6PD A-mutation at nucleotide 202 arose relatively recently and in a single individual. Springer-Verlag, 1990 Beutler Ernest Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Kuhl Wanda Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Human Genetics Springer-Verlag 85/1(1990-06-01), 9-11 0340-6717 85:1<9 1990 85 439 https://doi.org/10.1007/BF00276317 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276317 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beutler Ernest Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Kuhl Wanda Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 9-11 0340-6717 85:1<9 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer