caa a22 4500 467984646 CHVBK 20180323112528.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276332 doi (NATIONALLICENCE)springer-10.1007/BF00276332 Loss of heterozygosity of the L-myc oncogene in human breast tumors [Elektronische Daten] [Ivan Bieche, Marie-Helene Champeme, Giorgio Merlo, Christian-Jacques Larsen, Robert Callahan, Rosette Lidereau] Summary: Recent studies suggest that loss of heterozygosity may play an important role in various human neoplasia. Cytogenetic abnormalities detected in primary breast tumors led us to examine breast tumor DNAs for deletions. In the present study, we demonstrate, using restriction fragment length polymorphism (RFLP) analysis at the L-myc proto-oncogene (chromosome 1p32), a frequent loss of heterozygosity in primary breast tumor DNAs (55 out of 152 informative tumor DNAs). Most of these deletions appear to be limited to chromosome 1p. No correlation was observed between this genetic alteration and several parameters of each patient's history or characteristics of the tumor. However, a significantly (P = 0.011) shorter survival period after relapse was observed for patients with loss of heterozygosity at L-myc in primary tumor DNAs compared with patients with tumor DNAs lacking this alteration. Springer-Verlag, 1990 Bieche Ivan Centre René Huguenin, 5, Rue Gaston Latouche, F-92211, St. Cloud, France aut Champeme Marie-Helene Centre René Huguenin, 5, Rue Gaston Latouche, F-92211, St. Cloud, France aut Merlo Giorgio Laboratory of Tumor Immunology and Biology, NCI, National Institute of Health, 20892, Bethesda, MD, USA aut Larsen Christian-Jacques Unité INSERM 301, IGM, 27, Rue Charlotte Dodu, F-75011, Paris, France aut Callahan Robert Laboratory of Tumor Immunology and Biology, NCI, National Institute of Health, 20892, Bethesda, MD, USA aut Lidereau Rosette Centre René Huguenin, 5, Rue Gaston Latouche, F-92211, St. Cloud, France aut Human Genetics Springer-Verlag 85/1(1990-06-01), 101-105 0340-6717 85:1<101 1990 85 439 https://doi.org/10.1007/BF00276332 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276332 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bieche Ivan Centre René Huguenin, 5, Rue Gaston Latouche, F-92211, St. Cloud, France aut NATIONALLICENCE 700 1- Champeme Marie-Helene Centre René Huguenin, 5, Rue Gaston Latouche, F-92211, St. Cloud, France aut NATIONALLICENCE 700 1- Merlo Giorgio Laboratory of Tumor Immunology and Biology, NCI, National Institute of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Larsen Christian-Jacques Unité INSERM 301, IGM, 27, Rue Charlotte Dodu, F-75011, Paris, France aut NATIONALLICENCE 700 1- Callahan Robert Laboratory of Tumor Immunology and Biology, NCI, National Institute of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Lidereau Rosette Centre René Huguenin, 5, Rue Gaston Latouche, F-92211, St. Cloud, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 101-105 0340-6717 85:1<101 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer