caa a22 4500 467984654 CHVBK 20180323112528.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276321 doi (NATIONALLICENCE)springer-10.1007/BF00276321 A deletion panel of the long arm of the X chromosome: subregional localization of 22 DNA probes [Elektronische Daten] [H. Yang, T. Lund, E. Niebuhr, S. Nørby, M. Schwartz, L. Shen] Summary: Two males and two females with different but overlapping deletions on the proximal long arm of the X chromosomes have been investigated. Their karyotypes, which have been well characterized by high resolution banding techniques, are 46,Y,del(X)(pter→q21.1:: q21.33→qter); 46,Y,del(X) (pter→q21.2::q21.31→qter); 46,X,del(X) (pter→q21.31::q24.3→qter) and 46,X,del (X)(pter→q21.1:). A deletion panel, which makes it possible to subdivide the long arm of the X chromosome into seven subregions, has been established using the genomic DNA from the four families, and applied to the fine subregional localization of the loci for 22 DNA probes. Based on the results obtained, the possible location of the loci in question has been narrowed down considerably, in some cases to an area of only 5% of the previously assigned region; hybridization to Southern blots of a panel with well-characterized chromosome deletions is thus a powerful means of localizing DNA probes, especially with respect to the X probes. Springer-Verlag, 1990 Yang H. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut Lund T. Department of Clinical Chemistry, Rigshospitalet, DK-2100, Copenhagen, Denmark aut Niebuhr E. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut Nørby S. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut Schwartz M. Section of Clinical Genetics, Rigshospitalet, DK-2100, Copenhagen, Denmark aut Shen L. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut Human Genetics Springer-Verlag 85/1(1990-06-01), 25-30 0340-6717 85:1<25 1990 85 439 https://doi.org/10.1007/BF00276321 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276321 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang H. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Lund T. Department of Clinical Chemistry, Rigshospitalet, DK-2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Niebuhr E. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Nørby S. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Schwartz M. Section of Clinical Genetics, Rigshospitalet, DK-2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Shen L. Institute of Medical Genetics, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 25-30 0340-6717 85:1<25 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer