caa a22 4500 467984662 CHVBK 20180323112528.0 cr unu---uuuuu 170328e19900601xx s 000 0 eng 10.1007/BF00276319 doi (NATIONALLICENCE)springer-10.1007/BF00276319 Paracentric inversion inv(11) (q21q23) in the Netherlands [Elektronische Daten] [K. Madan, M. Pieters, L. Kuyt, C. van Asperen, J. de Pater, A. Hamers, K. Gerssen-Schoorl, T. Hustinx, A. Breed, J. Van Hemel, D. Smeets] Summary: We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant chromosomes arising from the inversion. It is doubtful whether prenatal diagnosis would be helpful to carriers of this inversion. The results of the genealogy study and geographical distribution are discussed; it is suggested that all the families have arisen from a single mutation. Springer-Verlag, 1990 Madan K. Institute of Human Genetics, Free University, Postbus 7057, NL-1007, MB Amsterdam, The Netherlands aut Pieters M. Department of Genetics and Cell Biology, University of Limburg, Postbus 616, NL-6200, MD Maastricht, The Netherlands aut Kuyt L. Institute of Human Genetics, Free University, Postbus 7057, NL-1007, MB Amsterdam, The Netherlands aut van Asperen C. Institute of Human Genetics, University of Amsterdam, Meibergdreef 15, NL-1105, AZ Amsterdam, The Netherlands aut de Pater J. Clinical Genetics Centre, Postbus 18009, NL-3501, CA Utrecht, The Netherlands aut Hamers A. Department of Genetics and Cell Biology, University of Limburg, Postbus 616, NL-6200, MD Maastricht, The Netherlands aut Gerssen-Schoorl K. Regional Pathological Laboratory, Edo Bergsmalaan 1, NL-7512, AD Enschede, The Netherlands aut Hustinx T. Institute of Human Genetics, Catholic University of Nijmegen, Geert Grooteplein Zuid 10, NL-6500, HB Nijmegen, The Netherlands aut Breed A. Institute of Human Genetics, University of Groningen, Antonius Deusinglaan 4, NL-9713, AW Groningen, The Netherlands aut Van Hemel J. Department of Clinical Genetics, Dijkzigt Academic Hospital, Erasmus University, Postbus 1738, NL-3000, DR Rotterdam, The Netherlands aut Smeets D. Institute of Human Genetics, Catholic University of Nijmegen, Geert Grooteplein Zuid 10, NL-6500, HB Nijmegen, The Netherlands aut Human Genetics Springer-Verlag 85/1(1990-06-01), 15-20 0340-6717 85:1<15 1990 85 439 https://doi.org/10.1007/BF00276319 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00276319 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madan K. Institute of Human Genetics, Free University, Postbus 7057, NL-1007, MB Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Pieters M. Department of Genetics and Cell Biology, University of Limburg, Postbus 616, NL-6200, MD Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Kuyt L. Institute of Human Genetics, Free University, Postbus 7057, NL-1007, MB Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Asperen C. Institute of Human Genetics, University of Amsterdam, Meibergdreef 15, NL-1105, AZ Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Pater J. Clinical Genetics Centre, Postbus 18009, NL-3501, CA Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Hamers A. Department of Genetics and Cell Biology, University of Limburg, Postbus 616, NL-6200, MD Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Gerssen-Schoorl K. Regional Pathological Laboratory, Edo Bergsmalaan 1, NL-7512, AD Enschede, The Netherlands aut NATIONALLICENCE 700 1- Hustinx T. Institute of Human Genetics, Catholic University of Nijmegen, Geert Grooteplein Zuid 10, NL-6500, HB Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Breed A. Institute of Human Genetics, University of Groningen, Antonius Deusinglaan 4, NL-9713, AW Groningen, The Netherlands aut NATIONALLICENCE 700 1- Van Hemel J. Department of Clinical Genetics, Dijkzigt Academic Hospital, Erasmus University, Postbus 1738, NL-3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Smeets D. Institute of Human Genetics, Catholic University of Nijmegen, Geert Grooteplein Zuid 10, NL-6500, HB Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/1(1990-06-01), 15-20 0340-6717 85:1<15 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer