caa a22 4500 467984832 CHVBK 20180323112528.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00193597 doi (NATIONALLICENCE)springer-10.1007/BF00193597 A new Hae III polymorphism at the D21S13 locus [Elektronische Daten] [S. Pulst, J. Korenberg, M. Ren, J. Greenwald] Summary: DNA markers in the pericentromeric region of human chromosome 21 have shown linkage to a gene for Familial Alzheimer disease (FAD; St. George Hyslop et al. 1987). The limited informativeness of probes for the loci D21S13 and D21S16 have hindered precise mapping of the FAD locus and analysis of non-allelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We recently described a new EcoRII polymorphism at the D21S13 locus that was very informative in a large FAD pedigree (Pulst et al. 1990a, b). We now report another polymorphism for the D21S13 locus that further increases the informativeness of this locus. Springer-Verlag, 1990 Pulst S. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut Korenberg J. Division of Medical Genetics, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut Ren M. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut Greenwald J. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut Human Genetics Springer-Verlag 85/6(1990-10-01), 671-671 0340-6717 85:6<671 1990 85 439 https://doi.org/10.1007/BF00193597 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193597 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pulst S. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Korenberg J. Division of Medical Genetics, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Ren M. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Greenwald J. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/6(1990-10-01), 671-671 0340-6717 85:6<671 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer