caa a22 4500 467984859 CHVBK 20180323112528.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00193576 doi (NATIONALLICENCE)springer-10.1007/BF00193576 Identification and characterization of normal length nonfluorescent Y chromosomes: cytogenetic analysis, Southern hybridization and non-isotopic in situ hybridization [Elektronische Daten] [Frank Speleman, Bart Van der Auwera, Kathelijne Mangelschots, Miet Vercruyssen, Ton Raap, Joop Wiegant, Margarita Craen, Jules Leroy] Summary: In two female patients with a 45,X/46,X,+mar karyotype the marker chromosomes were identified as normal length nonfluorescent Y chromosomes (nlYnf) using non-isotopic in situ hybridization (NISH) complementary to routine cytogenetic analysis and Southern hybridization. The recognition of the nlYnf as isodicentric in both patients illustrates and confirms the usefulness and importance of NISH in the identification and characterization of this and many other types of complex chromosome rearrangements. Springer-Verlag, 1990 Speleman Frank Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut Van der Auwera Bart Department of Medical Genetics, University of Antwerp, B-2610, Wilrÿk, Belgium aut Mangelschots Kathelijne Department of Medical Genetics, University of Antwerp, B-2610, Wilrÿk, Belgium aut Vercruyssen Miet Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut Raap Ton Department of Cytochemistry and Cytometry, University of Leiden, NL-2333, AL Leiden, The Netherlands aut Wiegant Joop Department of Cytochemistry and Cytometry, University of Leiden, NL-2333, AL Leiden, The Netherlands aut Craen Margarita Department of Pediatrics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut Leroy Jules Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut Human Genetics Springer-Verlag 85/6(1990-10-01), 569-575 0340-6717 85:6<569 1990 85 439 https://doi.org/10.1007/BF00193576 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193576 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Speleman Frank Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut NATIONALLICENCE 700 1- Van der Auwera Bart Department of Medical Genetics, University of Antwerp, B-2610, Wilrÿk, Belgium aut NATIONALLICENCE 700 1- Mangelschots Kathelijne Department of Medical Genetics, University of Antwerp, B-2610, Wilrÿk, Belgium aut NATIONALLICENCE 700 1- Vercruyssen Miet Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut NATIONALLICENCE 700 1- Raap Ton Department of Cytochemistry and Cytometry, University of Leiden, NL-2333, AL Leiden, The Netherlands aut NATIONALLICENCE 700 1- Wiegant Joop Department of Cytochemistry and Cytometry, University of Leiden, NL-2333, AL Leiden, The Netherlands aut NATIONALLICENCE 700 1- Craen Margarita Department of Pediatrics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut NATIONALLICENCE 700 1- Leroy Jules Department of Medical Genetics, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/6(1990-10-01), 569-575 0340-6717 85:6<569 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer