caa a22 4500 467984921 CHVBK 20180323112529.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00193583 doi (NATIONALLICENCE)springer-10.1007/BF00193583 Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas [Elektronische Daten] [Mef Nilbert, Sverre Heim, Nils Mandahl, Ulla-Maria Flodérus, Helena Willén, Felix Mitelman] Summary: The cytogenetic analysis of 224 leiomyomas from 138 patients is presented. An insufficient number of mitoses was found in 35 tumors, normal karyotypes in 145, and clonal chromosome aberrations were detected in 44. The three previously identified cytogenetic subgroups were all represented in this series: del(7) (q21.2q31.2) was found in 11, trisomy 12 in five, and t(12;14)(q14-15;q23-24) in one leiomyoma. Rearrangements of 6p, including deletions, inversions, and various translocations, were found in eight tumors, thus delineating a new cytogenetic subgroup of uterine leiomyoma. The remaining 21 karyotypically abnormal tumors had nonrecurrent changes. One leiomyoma had two cytogenetically unrelated clones characterized by del(7)(q21.2 q31.2) and +12. Karyotypic changes in two separate leiomyomas from the same uterus were identified in five patients; in three of them, different anomalies were found in the two tumors, whereas cytogenetically identical aberrations − del(7q) and dic(21;22) − were detected in two macroscopically discrete tumors. These findings suggest that whereas some multiple leiomyomas originate independently, others may be derived from the same neoplastic clone. Springer-Verlag, 1990 Nilbert Mef Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut Heim Sverre Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut Mandahl Nils Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut Flodérus Ulla-Maria Department of Gynecology, University Hospital, S-221 85, Lund, Sweden aut Willén Helena Department of Clinical Pathology, University Hospital, S-221 85, Lund, Sweden aut Mitelman Felix Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut Human Genetics Springer-Verlag 85/6(1990-10-01), 605-611 0340-6717 85:6<605 1990 85 439 https://doi.org/10.1007/BF00193583 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00193583 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nilbert Mef Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Heim Sverre Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Mandahl Nils Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Flodérus Ulla-Maria Department of Gynecology, University Hospital, S-221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Willén Helena Department of Clinical Pathology, University Hospital, S-221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Mitelman Felix Department of Clinical Genetics, University Hospital, S-221 85, Lund, Sweden aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/6(1990-10-01), 605-611 0340-6717 85:6<605 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer