caa a22 4500 467985030 CHVBK 20180323112529.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206758 doi (NATIONALLICENCE)springer-10.1007/BF00206758 Chromosomes 17 and 22 involved in marker formation in neurofibrosarcoma in von Recklinghausen disease [Elektronische Daten] A cytogenetic and in situ hybridization study [Hans-Joachim Decker, Linda Cannizzaro, Michael Mendez, Stanley Leong, Helen Bixenman, Carol Berger, Avery Sandberg] Summary: We describe the cytogenetic findings in a recurrent neurofibrosarcoma in a patient with nonfamilial von Recklinghausen disease. The composite karyotype was: 40,Y,-X,+dic r(X;20)(:Xp22.2→q26::20p13→ q13:), -1, +der(1)t(1;3) (p21;p24),-3,-4,-5,+der(5) t(5;?)(q31;?),-9,-9,+der(9)t(3;9)(q21 or q13;p24 or p22), -11,+der(11)t(11;?)(q22.2;?), -17,+der(17)t(17; 22;?)(q21;q13.1;?), -20, -21, -22, -22, +der(22)t(17; 22;?)(q21;q13.1;?),t(2;10)(q37;q22). The derivative chromosomes were demonstrated at the 500 band level. Chromosomes 17 and 22 were shown to be involved in an unbalanced three-way translocation: t(17;22;?)(q21;q13.1;?). This event was confirmed by in situ hybridization, using two probes mapped to chromosome 17. Hill H is a probe derived from the novel oncogene TRE and is located at 17q12-22. The second probe, derived from the granulocyte colony-stimulating factor (G-CSF), is located at 17q11-q21. The rearrangement between chromosomes 17 and 22 showed breakpoints similar or close to the gene loci for neurofibromatosis 1 (NF-1) and NF-2. Based on our observations we recommend that genetic studies on NF-1 tumors include both gene sites (NF-1 and NF-2) rather than focus on one gene locus. Springer-Verlag, 1990 Decker Hans-Joachim The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut Cannizzaro Linda The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut Mendez Michael The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut Leong Stanley Department of Surgery, Arizona Cancer Center, University of Arizona Health Services Center, 85724, Tucson, AZ, USA aut Bixenman Helen The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut Berger Carol The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut Sandberg Avery The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut Human Genetics Springer-Verlag 85/3(1990-08-01), 337-342 0340-6717 85:3<337 1990 85 439 https://doi.org/10.1007/BF00206758 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206758 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Decker Hans-Joachim The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Cannizzaro Linda The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Mendez Michael The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Leong Stanley Department of Surgery, Arizona Cancer Center, University of Arizona Health Services Center, 85724, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Bixenman Helen The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Berger Carol The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Sandberg Avery The Cancer Center of the Southwest Biomedical Research Institute, 85251, Scottsdale, AZ, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 337-342 0340-6717 85:3<337 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer