caa a22 4500 467985103 CHVBK 20180323112529.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206747 doi (NATIONALLICENCE)springer-10.1007/BF00206747 Risk of nonocular cancer in first-degree relatives of retinoblastoma patients [Elektronische Daten] [Jørgen Olsen, Jens Winther, Peter Brown] Summary: The increased risk of nonocular cancer seen consistently in studies of survivors of retinoblastoma may be caused in part by the presence of a retinoblastoma gene that also predisposes to other cancers. It has been claimed that this gene also increases the risk for cancer among unaffected relatives of genetic retinoblastoma probands. We report here a population-based study of the risk of nonocular cancer in parents and siblings of persons notified to the Danish Cancer Registry with retinoblastoma during 1943-84. No excess was observed among first degree relatives of 61 genetic retinoblastoma probands, whereas a slight (10%) excess was seen among the parents of 115 nongenetic probands. The latter was the result of significant excesses of malignant melanoma (4 observed, 0.4 expected), multiple myeloma (2 observed, 0.2 expected) and osteogenic sarcoma (1 observed, 0.03 expected). The observed risk pattern cannot be explained by the presence of the retinoblastoma gene. Springer-Verlag, 1990 Olsen Jørgen Danish Cancer Registry, Institute of Cancer Epidemiology, Rosenvængets Hovedvej 35, Box 839, DK-2100, Copenhagen, Denmark aut Winther Jens Department of Ophthalmology, Holstebro Centralsygehus, DK-7500, Holstebro, Denmark aut Brown Peter Danish Cancer Registry, Institute of Cancer Epidemiology, Rosenvængets Hovedvej 35, Box 839, DK-2100, Copenhagen, Denmark aut Human Genetics Springer-Verlag 85/3(1990-08-01), 283-287 0340-6717 85:3<283 1990 85 439 https://doi.org/10.1007/BF00206747 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206747 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Olsen Jørgen Danish Cancer Registry, Institute of Cancer Epidemiology, Rosenvængets Hovedvej 35, Box 839, DK-2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Winther Jens Department of Ophthalmology, Holstebro Centralsygehus, DK-7500, Holstebro, Denmark aut NATIONALLICENCE 700 1- Brown Peter Danish Cancer Registry, Institute of Cancer Epidemiology, Rosenvængets Hovedvej 35, Box 839, DK-2100, Copenhagen, Denmark aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 283-287 0340-6717 85:3<283 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer