caa a22 4500 467985111 CHVBK 20180323112529.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206753 doi (NATIONALLICENCE)springer-10.1007/BF00206753 Improved carrier detection of haemophilia A using novel RFLPs at the DXS115 (767) locus [Elektronische Daten] [P. Jedlicka, S. Greer, D. Millar, C. Grundy, E. Jenkins, M. Mitchell, R. Mibashan, V. Kakkar, D. Cooper] Summary: Two novel restriction fragment length polymorphisms (RFLPs) around the DXS115 (767) locus, detectable with the restriction enzymes MspI, are described. Since DXS115 is closely linked to the factor VIII gene (F8C), the MspI RFLP was employed in haemophilia A carrier detection. The utility of these RFLPs lies in the increased applicability and accuracy of diagnoses carried out in cases where available intragenic markers are uninformative. Springer-Verlag, 1990 Jedlicka P. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut Greer S. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut Millar D. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut Grundy C. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut Jenkins E. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut Mitchell M. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut Mibashan R. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut Kakkar V. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut Cooper D. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut Human Genetics Springer-Verlag 85/3(1990-08-01), 315-318 0340-6717 85:3<315 1990 85 439 https://doi.org/10.1007/BF00206753 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jedlicka P. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut NATIONALLICENCE 700 1- Greer S. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut NATIONALLICENCE 700 1- Millar D. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Grundy C. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Jenkins E. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut NATIONALLICENCE 700 1- Mitchell M. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut NATIONALLICENCE 700 1- Mibashan R. Haematology Department, King's College Hospital, Denmark Hill, SE5 8RS, London, UK aut NATIONALLICENCE 700 1- Kakkar V. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Cooper D. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 315-318 0340-6717 85:3<315 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer