caa a22 4500 467985154 CHVBK 20180323112529.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206760 doi (NATIONALLICENCE)springer-10.1007/BF00206760 Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies [Elektronische Daten] [Anne Bowcock, Vittorio Sartorelli] Summary: Probes detecting restriction fragment length polymorphisms (RFLPs) in the insulinlike growth factor (IGF1) gene were isolated and allele frequencies in different human populations determined. No difference was detected between the distribution of IGF1 alleles in Pygmies versus non-Pygmy black Africans, despite the proposal that a defect in the IGF1 gene might be responsible for Pygmy short stature. This was supported by the absence of a correlation of IGF1 genotype with height in the C.A.R. Pygmies. Polymerase chain reaction (PCR) and direct sequencing failed to demonstrate an alteration in the region upstream the IGF1 start site in Pygmies. Linkage analysis demonstrated that IGF1 is tightly linked to the phenylalanine hydroxylase gene on chromosome 12q22-24.1. Springer-Verlag, 1990 Bowcock Anne Department of Genetics, Stanford University, 94305, Stanford, CA, USA aut Sartorelli Vittorio Department of Genetics, Stanford University, 94305, Stanford, CA, USA aut Human Genetics Springer-Verlag 85/3(1990-08-01), 349-354 0340-6717 85:3<349 1990 85 439 https://doi.org/10.1007/BF00206760 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206760 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bowcock Anne Department of Genetics, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Sartorelli Vittorio Department of Genetics, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 349-354 0340-6717 85:3<349 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer