caa a22 4500 467985219 CHVBK 20180323112529.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206746 doi (NATIONALLICENCE)springer-10.1007/BF00206746 HLA class I gene polymorphism in genetic hemochromatosis [Elektronische Daten] [Anne-Marie Jouanolle, Jacqueline Yaouanq, Martine Blayau, Muriel Périchon, Renée Fauchet, Marie-Pierre Font, Jean-Yves Le Gall, Véronique David] Summary: The authors have studied HLA class I polymorphism in an attempt to identify a genomic marker of the hemochromatosis gene. Five enzymes were used (HindIII, EcoRI, EcoRV, PvuII, and HincII) in 47-106 unrelated patients and 71-91 controls. Both populations were HLA-typed. The relationship between the restriction fragments and HLA-A antigens was considered. Comparison of the two groups revealed a significantly high frequence of one 14kb EcoRI fragment among the HLA-A3 hemochromatosis patients. The fragment hybridizes to an HLA-A specific probe but not to an HLA-B specific probe, and is associated with the hemochromatosis gene, which is itself associated with HLA-A3. Springer-Verlag, 1990 Jouanolle Anne-Marie Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut Yaouanq Jacqueline Clinique Médicale B, INSERM U49, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut Blayau Martine Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut Périchon Muriel Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut Fauchet Renée Centre Régional de Transfusion sanguine, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut Font Marie-Pierre Unité INSERM U 93, Hôpital St. Louis, F-75010, Paris, France aut Le Gall Jean-Yves Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut David Véronique Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut Human Genetics Springer-Verlag 85/3(1990-08-01), 279-282 0340-6717 85:3<279 1990 85 439 https://doi.org/10.1007/BF00206746 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206746 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jouanolle Anne-Marie Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 700 1- Yaouanq Jacqueline Clinique Médicale B, INSERM U49, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 700 1- Blayau Martine Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 700 1- Périchon Muriel Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 700 1- Fauchet Renée Centre Régional de Transfusion sanguine, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 700 1- Font Marie-Pierre Unité INSERM U 93, Hôpital St. Louis, F-75010, Paris, France aut NATIONALLICENCE 700 1- Le Gall Jean-Yves Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 700 1- David Véronique Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 279-282 0340-6717 85:3<279 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer