caa a22 4500 467985243 CHVBK 20180323112530.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206741 doi (NATIONALLICENCE)springer-10.1007/BF00206741 Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families [Elektronische Daten] [Ichiro Kanazawa, Ikuko Kondo, Joh-E Ikeda, Teruaki Ikeda, Yuichior Shizu, Mitsuo Yoshida, Hirotaro Narabayashi, Shigetoshi Kuroda, Hisayuki Tsunoda, Eiji Mizuta, Yoko Okuno, Kiyotaka Sugawara, Miho Murata, Mafuyu Takahashi, James Gusella] Summary: This is the first full report on the genetic linkage between Japanese Huntington's disease and the DNA markers D4S10 and D4S43/S127. With use of the HindIII, BglI, and EcoRI polymorphisms detected at D4S10, and the combination of all these polymorphisms to give composite haplotypes, nine Japanese Huntington's disease families were found to be informative. Three recombinants for D4S10 were detected in these families, giving a maximum lod score of 1.662 at a θ of 0.10. Similarly, when we used the MspI and PvuII polymorphisms detected by D4S43/S127, five families gave informative results. No recombinant was detected in these families, giving a maximum lod score of 3.348 at a θof 0.00. These results clearly support the view that the Japanese Huntington's disease gene may be identical with the Western gene, in spite of the lower prevalence rate in Japan. Springer-Verlag, 1990 Kanazawa Ichiro Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 305, Tsukuba-City, Japan aut Kondo Ikuko Department of Ecology and Genetics, School of Health Sciences, Faculty of Medicine, University of Ryukyus, Okinawa, Japan aut Ikeda Joh-E Laboratory for Controls of Gene Expression, National Institute of Agrobiological Researches, Tsukuba-City, Japan aut Ikeda Teruaki Division of Psychiatry, Otaru Second Municipal Hospital, Otaru, Japan aut Shizu Yuichior Division of Psychiatry, Ishigoh-oka Hospital, Chiba, Japan aut Yoshida Mitsuo Department of Neurology, Jichi Medical School, Tochigi, Japan aut Narabayashi Hirotaro Neurological Clinic, Naka-meguro, Tokyo, Japan aut Kuroda Shigetoshi Department of Psychiatry, Okayama University, Okayama, Japan aut Tsunoda Hisayuki Division of Neurology, Tokyo Municipal Hospital for Neurological Disease, Fuchu, Tokyo, Japan aut Mizuta Eiji Division of Neurology, National Utano Hospital, Kyoto, Japan aut Okuno Yoko Division of Psychiatry, Hara Hospital, Gumma, Japan aut Sugawara Kiyotaka Division of Pediatrics, Nishi-kohfu Hospital, Kohfu, Japan aut Murata Miho Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 305, Tsukuba-City, Japan aut Takahashi Mafuyu Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan aut Gusella James Neurogenetics Laboratory Massachusetts General Hospital, 02129, Boston, MA, USA aut Human Genetics Springer-Verlag 85/3(1990-08-01), 257-260 0340-6717 85:3<257 1990 85 439 https://doi.org/10.1007/BF00206741 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206741 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kanazawa Ichiro Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 305, Tsukuba-City, Japan aut NATIONALLICENCE 700 1- Kondo Ikuko Department of Ecology and Genetics, School of Health Sciences, Faculty of Medicine, University of Ryukyus, Okinawa, Japan aut NATIONALLICENCE 700 1- Ikeda Joh-E Laboratory for Controls of Gene Expression, National Institute of Agrobiological Researches, Tsukuba-City, Japan aut NATIONALLICENCE 700 1- Ikeda Teruaki Division of Psychiatry, Otaru Second Municipal Hospital, Otaru, Japan aut NATIONALLICENCE 700 1- Shizu Yuichior Division of Psychiatry, Ishigoh-oka Hospital, Chiba, Japan aut NATIONALLICENCE 700 1- Yoshida Mitsuo Department of Neurology, Jichi Medical School, Tochigi, Japan aut NATIONALLICENCE 700 1- Narabayashi Hirotaro Neurological Clinic, Naka-meguro, Tokyo, Japan aut NATIONALLICENCE 700 1- Kuroda Shigetoshi Department of Psychiatry, Okayama University, Okayama, Japan aut NATIONALLICENCE 700 1- Tsunoda Hisayuki Division of Neurology, Tokyo Municipal Hospital for Neurological Disease, Fuchu, Tokyo, Japan aut NATIONALLICENCE 700 1- Mizuta Eiji Division of Neurology, National Utano Hospital, Kyoto, Japan aut NATIONALLICENCE 700 1- Okuno Yoko Division of Psychiatry, Hara Hospital, Gumma, Japan aut NATIONALLICENCE 700 1- Sugawara Kiyotaka Division of Pediatrics, Nishi-kohfu Hospital, Kohfu, Japan aut NATIONALLICENCE 700 1- Murata Miho Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 305, Tsukuba-City, Japan aut NATIONALLICENCE 700 1- Takahashi Mafuyu Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Gusella James Neurogenetics Laboratory Massachusetts General Hospital, 02129, Boston, MA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 257-260 0340-6717 85:3<257 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer