caa a22 4500 467985251 CHVBK 20180323112530.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206757 doi (NATIONALLICENCE)springer-10.1007/BF00206757 Pericentromeric structure of human X "isochromosomes”: evidence for molecular heterogeneity [Elektronische Daten] [Cecil Sharp, H. Bedford, Huntington Willard] Summary: Three different long-arm X isochromosomes and an isodicentric X chromosome were examined by in situ hybridization with X-chromosome-specific α-satellite probes and by quantitation of Southern blots hybridized with proximal short-arm probes. Each chromosome had a unique pericentromeric structure. The isodicentric X chromosome was clearly dicentric, showing two distinct α-satellite hybridization signals and duplication of short-arm material. Two isochromosomes showed a larger than normal, bifid α-satellite signal and also had duplications of different extents of short-arm material. The third X isochromosome could not be distinguished from a classical long-arm isochromosome; it did not have a short-arm duplication and it had a single α-satellite signal. These data indicate that rearrangements responsible for X isochromosome formation can occur at numerous locations in the pericentromeric region and that some X isochromosomes may involve duplications of substantial portions of the short arm. Springer-Verlag, 1990 Sharp Cecil Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Bedford H. Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Willard Huntington Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Human Genetics Springer-Verlag 85/3(1990-08-01), 330-336 0340-6717 85:3<330 1990 85 439 https://doi.org/10.1007/BF00206757 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206757 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sharp Cecil Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Bedford H. Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Willard Huntington Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 330-336 0340-6717 85:3<330 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer