caa a22 4500 46798526X CHVBK 20180323112530.0 cr unu---uuuuu 170328e19900801xx s 000 0 eng 10.1007/BF00206751 doi (NATIONALLICENCE)springer-10.1007/BF00206751 Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy [Elektronische Daten] [Kathryn Walsh, Helen Harley, J. Brook, Shelley Rundle, Mansoor Sarfarazi, Peter Harper, Duncan Shaw] Summary: We have studied the genetic linkage of two markers, the apolipoprotein C1 (APOC1) gene and a cytochrome P450 (CYP2A) gene, in relation to the gene for myotonic dystrophy (DM). A peak lod score of 9.29 at 2 cM was observed for APOC1-DM, with a lod score of 8.55 at 4cM for CYP2A-DM. These two markers also show close linkage to each other (θ max = 0.05, Z max = 9.09). From examination of the genotypes of the recombinant individuals, CYP2A appears to map proximal to DM because in one recombinant individual CYP2A, APOC2 and CKMM had all recombined with DM. Evidence from another CYP2A-DM recombinant individual places CYP2A proximal to APOC2 and CKMM. Localisation of CYP2A on a panel of somatic cell hybrids also suggests that it is proximal to DM and APOC2/C1/E gene cluster. Springer-Verlag, 1990 Walsh Kathryn Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Harley Helen Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Brook J. Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Rundle Shelley Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Sarfarazi Mansoor Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Harper Peter Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Shaw Duncan Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut Human Genetics Springer-Verlag 85/3(1990-08-01), 305-310 0340-6717 85:3<305 1990 85 439 https://doi.org/10.1007/BF00206751 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00206751 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walsh Kathryn Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 700 1- Harley Helen Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 700 1- Brook J. Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 700 1- Rundle Shelley Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 700 1- Sarfarazi Mansoor Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 700 1- Harper Peter Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 700 1- Shaw Duncan Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/3(1990-08-01), 305-310 0340-6717 85:3<305 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer