caa a22 4500 467985367 CHVBK 20180323112530.0 cr unu---uuuuu 170328e19900901xx s 000 0 eng 10.1007/BF02428278 doi (NATIONALLICENCE)springer-10.1007/BF02428278 Frequency of deletion 508 among Irish cystic fibrosis patients [Elektronische Daten] [Miguel De Arce, Diarmuid Mulherin, Peter McWilliam, Mark Lawler, M. FitzGerald, Peter Humphries] Summary: We estimate the incidence of cystic fibrosis in Ireland to be at least 1 case per 1838 live births. We have analysed DNA from 44 Irish CF patients for the presence of deletion 508, using the polymerase chain reaction. The deletion was found in 76% of their chromosomes, and approximately 58% of the patients are homozygous for this deletion. Our results are not significantly different from those found in Canadian or UK patient populations, in which frequencies are higher than those found in Southern European countries. Springer-Verlag, 1990 De Arce Miguel Department of Genetics, Trinity College, Dublin 2, Ireland aut Mulherin Diarmuid Medical Professorial Unit, University College and St. Vincent's Hospital, Dublin 4, Ireland aut McWilliam Peter Department of Genetics, Trinity College, Dublin 2, Ireland aut Lawler Mark Department of Genetics, Trinity College, Dublin 2, Ireland aut FitzGerald M. Medical Professorial Unit, University College and St. Vincent's Hospital, Dublin 4, Ireland aut Humphries Peter Department of Genetics, Trinity College, Dublin 2, Ireland aut Human Genetics Springer-Verlag 85/4(1990-09-01), 403-404 0340-6717 85:4<403 1990 85 439 https://doi.org/10.1007/BF02428278 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02428278 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Arce Miguel Department of Genetics, Trinity College, Dublin 2, Ireland aut NATIONALLICENCE 700 1- Mulherin Diarmuid Medical Professorial Unit, University College and St. Vincent's Hospital, Dublin 4, Ireland aut NATIONALLICENCE 700 1- McWilliam Peter Department of Genetics, Trinity College, Dublin 2, Ireland aut NATIONALLICENCE 700 1- Lawler Mark Department of Genetics, Trinity College, Dublin 2, Ireland aut NATIONALLICENCE 700 1- FitzGerald M. Medical Professorial Unit, University College and St. Vincent's Hospital, Dublin 4, Ireland aut NATIONALLICENCE 700 1- Humphries Peter Department of Genetics, Trinity College, Dublin 2, Ireland aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/4(1990-09-01), 403-404 0340-6717 85:4<403 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer