caa a22 4500 467985383 CHVBK 20180323112530.0 cr unu---uuuuu 170328e19900901xx s 000 0 eng 10.1007/BF02428288 doi (NATIONALLICENCE)springer-10.1007/BF02428288 The frequency of the ΔF508 mutation on cystic fibrosis chromosomes in Israeli families: correlation to CF haplotypes in Jewish communities and Arabs [Elektronische Daten] [I. Lerer, S. Cohen, M. Chemke, A. Sanilevich, J. Rivlin, A. Golan, J. Yahav, A. Friedman, D. Abeliovich] Summary: We have analysed the distribution of the ΔF508 mutation and the haplotypes of cystic fibrosis (CF) bearing chromosomes among the Israeli CF population. The population was classified according to its ethnic origin and included 3 groups, Ashkenazi Jews, Sephardic/Oriental Jews and Arabs. Haplotype B (KM19 allele 2, XV2c allele 1) was found to be the predominant haplotype in all groups but in each of them the haplotype distribution was different. The ΔF508 mutation was present in all groups and accounts for 32% of the CF mutations. It was mainly associated with the B haplotype but only one third of the CF chromosomes with this haplotype carry the ΔF508 mutation. Springer-Verlag, 1990 Lerer I. Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel aut Cohen S. Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel aut Chemke M. Clinical Genetics Unit, Kaplan Hospital, Rehovot, Israel aut Sanilevich A. Molecular Biology Unit, Hadassah University Hospital, Jerusalem, Israel aut Rivlin J. Carmel Hospital, Haifa, Israel aut Golan A. Soroka University Hospital, Beer Sheva, Israel aut Yahav J. Chaim Sheba Medical Center, Tel Hashomer, Israel aut Friedman A. Molecular Biology Unit, Hadassah University Hospital, Jerusalem, Israel aut Abeliovich D. Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel aut Human Genetics Springer-Verlag 85/4(1990-09-01), 416-417 0340-6717 85:4<416 1990 85 439 https://doi.org/10.1007/BF02428288 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02428288 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lerer I. Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 700 1- Cohen S. Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 700 1- Chemke M. Clinical Genetics Unit, Kaplan Hospital, Rehovot, Israel aut NATIONALLICENCE 700 1- Sanilevich A. Molecular Biology Unit, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 700 1- Rivlin J. Carmel Hospital, Haifa, Israel aut NATIONALLICENCE 700 1- Golan A. Soroka University Hospital, Beer Sheva, Israel aut NATIONALLICENCE 700 1- Yahav J. Chaim Sheba Medical Center, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Friedman A. Molecular Biology Unit, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 700 1- Abeliovich D. Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/4(1990-09-01), 416-417 0340-6717 85:4<416 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer