caa a22 4500 467985707 CHVBK 20180323112531.0 cr unu---uuuuu 170328e19901001xx s 000 0 eng 10.1007/BF00194220 doi (NATIONALLICENCE)springer-10.1007/BF00194220 Leukaemia and transient leukaemia in Down syndrome [Elektronische Daten] [Lennart Iselius, Patricia Jacobs, Newton Morton] Summary: We have reviewed 215 published cases of leukaemia and transient leukaemia in Down syndrome. There is an over-representation of mosaic trisomy 21, possibly the result, at least in part, of a survival effect. The most intriguing observation is a bimodal distribution of maternal age, produced largely because cases with true leukaemia have a significantly higher maternal age than cases with transient leukaemia (33.5 versus 29.5 years). In conjunction with evidence that meiosis I non-disjunction is infrequent in transient leukaemia, this suggests different mechanisms for the etiology of leukaemia and transient leukaemia, and favours a locus predisposing to transient leukaemia proximal to the centromere on the long arm of chromosome 21. Springer-Verlag, 1990 Iselius Lennart CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, S09 4XY, Southampton, UK aut Jacobs Patricia Wessex Regional Cytogenetics Unit, Salisbury General Hospital, Salisbury, UK aut Morton Newton CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, S09 4XY, Southampton, UK aut Human Genetics Springer-Verlag 85/5(1990-10-01), 477-485 0340-6717 85:5<477 1990 85 439 https://doi.org/10.1007/BF00194220 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00194220 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iselius Lennart CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, S09 4XY, Southampton, UK aut NATIONALLICENCE 700 1- Jacobs Patricia Wessex Regional Cytogenetics Unit, Salisbury General Hospital, Salisbury, UK aut NATIONALLICENCE 700 1- Morton Newton CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, S09 4XY, Southampton, UK aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 85/5(1990-10-01), 477-485 0340-6717 85:5<477 1990 85 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer